FOSFONA VIAL 1VAIL

About

Fosfona VIAL contains fosfomycin, a unique phosphonic acid derivative antibiotic administered intravenously. It exerts its bactericidal effect by inhibiting an early stage of bacterial cell wall synthesis, specifically by inactivating the enzyme UDP-N-acetylglucosamine enolpyruvyl transferase. This distinct mechanism of action minimizes cross-resistance with other antibiotic classes, making it a valuable option against a broad spectrum of Gram-positive and Gram-negative bacteria, including many multi-drug resistant (MDR) strains.

Fosfona VIAL is particularly effective in treating complicated urinary tract infections (UTIs) and other severe infections where its broad activity and unique mechanism are advantageous. Its ability to achieve high concentrations in the urinary tract and other tissues makes it suitable for targeted therapy. Careful consideration of patient renal function and potential drug interactions is important to ensure safe and effective treatment.

Uses

• Treatment of complicated urinary tract infections (cUTIs).
• Management of severe bacterial infections caused by MDR strains.
• Prophylaxis for transurethral surgical procedures.
• Treatment of osteomyelitis (off-label use).

Directions For Use

Administer intravenously as directed by a healthcare professional. Dosage and duration depend on the infection's severity and patient response.

Benefits

• Broad spectrum of activity against Gram-positive and Gram-negative bacteria.
• Effective against multi-drug resistant (MDR) pathogens.
• Unique mechanism of action minimizes cross-resistance.
• Achieves high concentrations in the urinary tract.
• Valuable for complicated and severe infections.
• Can be used in combination therapy for synergistic effects.

Side Effects

• Nausea
• Diarrhea
• Headache
• Dizziness
• Abdominal pain
• Dyspepsia
• Rash
• Pruritus
• Vaginitis
• Asthenia
• Elevated liver enzymes
• Injection site reactions

Safety Measures

• Alcohol - Concurrent alcohol consumption may exacerbate gastrointestinal side effects. It is generally advisable to avoid alcohol during treatment.
• Pregnancy - Use during pregnancy should only be considered if the potential benefit outweighs the potential risk to the fetus. Consult a physician before use.
• Breastfeeding - Small amounts may pass into breast milk. Use with caution and monitor the infant for adverse effects. Consult a healthcare provider.
• Liver - Use with caution in patients with hepatic impairment. Dose adjustments may be necessary, and liver function should be monitored.
• Kidney - Dose adjustments are typically required for patients with renal impairment. Close monitoring of kidney function is essential during therapy.
• Lung - Generally safe for use in patients with lung conditions, but caution is advised in those with severe respiratory compromise or asthma due to potential allergic reactions.

Disclaimer

MedEHub is committed to delivering reliable, expert-reviewd information to help consumers make informed health decisions. However, the content provided on this website is for informational purposes only and is not intended to replace professional medical advice, diagnosis or treatment.

Always consult your doctor for any medical concerns, and discuss your questions about health conditions or medications with a qualified healthcare professional. Do not ignore or delay seeking professional medical advice based on information found on Med E Hub.

Our goal is to complement, not replace, the essential doctor-patient relationship.