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About

Itopride is a prokinetic agent specifically designed to enhance gastrointestinal motility and alleviate symptoms of functional dyspepsia. Its unique mechanism of action involves a dual approach: it acts as an antagonist at dopamine D2 receptors and simultaneously inhibits acetylcholinesterase. By blocking D2 receptors, itopride promotes the release of acetylcholine, a key neurotransmitter involved in gastrointestinal muscle contraction. Concurrently, its inhibition of acetylcholinesterase prevents the breakdown of this released acetylcholine, leading to higher and sustained concentrations of acetylcholine at the neuromuscular junctions within the gastrointestinal tract. This combined effect significantly strengthens gastric contractions, accelerates gastric emptying, and improves the coordinated movement of food through the digestive system. Consequently, itopride effectively reduces symptoms such as bloating, early satiety, upper abdominal pain, and nausea, offering substantial relief for patients suffering from impaired gastric motility.

Uses

• Treatment of functional dyspepsia
• Relief from bloating and abdominal discomfort
• Management of early satiety
• Alleviation of nausea and vomiting

Directions For Use

Take orally, usually before meals. Follow your doctor's prescribed dosage and duration.

Benefits

• Accelerates gastric emptying
• Reduces bloating and fullness
• Alleviates upper abdominal pain
• Improves digestion
• Relieves nausea and vomiting
• Enhances overall gastrointestinal motility

Side Effects

• Diarrhea
• Abdominal pain
• Headache
• Dizziness
• Nausea
• Constipation
• Increased salivation
• Tremor
• Rash
• Gynecomastia (rare, with prolonged use)
• Galactorrhea (rare, with prolonged use)
• Leukopenia (rare)

Safety Measures

• Alcohol - Alcohol may exacerbate gastrointestinal symptoms and could potentially interact with the medication's effects. It is generally advisable to limit or avoid alcohol.
• Pregnancy - Itopride is generally not recommended during pregnancy due to limited data on human safety. Use only if clearly necessary and under medical supervision.
• Breastfeeding - Itopride may be excreted in breast milk. It is generally not recommended during breastfeeding. Consult your doctor.
• Liver - Use with caution in patients with liver impairment. Dosage adjustments may be necessary, and liver function should be monitored.
• Kidney - Use with caution in patients with kidney impairment. Dosage adjustments may be necessary, and kidney function should be monitored.
• Lung - No specific safety concerns regarding lung conditions are typically associated with itopride.

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