Geftinat 250mg Tablet

About

Geftinat 250mg Tablet contains Gefitinib, a selective epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, designed to block the signaling pathways that promote cancer cell growth and survival. It specifically targets the ATP-binding site of the EGFR tyrosine kinase, thereby inhibiting autophosphorylation and downstream signaling. This mechanism is particularly effective in non-small cell lung cancer (NSCLC) patients harboring activating EGFR mutations, where it leads to significant tumor regression and improved progression-free survival. Gefitinib offers a targeted therapeutic approach, minimizing systemic toxicity compared to conventional chemotherapy, and has become a standard treatment option for eligible patients, significantly improving their prognosis and quality of life.

Uses

• Non-small cell lung cancer (NSCLC) with EGFR mutations.
• Advanced or metastatic NSCLC.
• First-line treatment for EGFR-mutated NSCLC.
• Patients who have failed prior chemotherapy.

Directions For Use

Take orally once daily, with or without food. Swallow the tablet whole.

Benefits

• Targeted therapy for EGFR-mutated NSCLC.
• Improves progression-free survival.
• Oral administration for convenience.
• Reduces tumor size and symptoms.
• Offers a non-chemotherapeutic option.
• Generally well-tolerated compared to traditional chemotherapy.

Side Effects

• Diarrhea
• Rash (acne-like)
• Nausea
• Vomiting
• Anorexia
• Stomatitis
• Dry skin
• Pruritus
• Liver enzyme elevation
• Interstitial lung disease (rare but serious)
• Ocular disorders (e.g., conjunctivitis)
• Asthenia

Safety Measures

• Alcohol - No specific interaction, but excessive alcohol can exacerbate gastrointestinal side effects and liver strain.
• Pregnancy - Contraindicated; can cause fetal harm. Effective contraception is required.
• Breastfeeding - Not recommended; discontinue breastfeeding during treatment due to potential harm to the infant.
• Liver - Use with caution in patients with hepatic impairment; monitor liver function closely. Dose adjustment may be needed.
• Kidney - Use with caution in patients with severe renal impairment; no specific dose adjustment typically needed for mild-moderate.
• Lung - Can cause severe interstitial lung disease (ILD), which can be fatal. Monitor for new or worsening respiratory symptoms.

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