GIFAXIN 400 10'S

About

Gifaxin 400mg contains Rifaximin, a non-systemic antibiotic that acts locally in the gastrointestinal tract. It is a broad-spectrum antibiotic that inhibits bacterial RNA synthesis by binding to the beta-subunit of bacterial DNA-dependent RNA polymerase. Due to its poor systemic absorption, rifaximin remains largely within the gut lumen, where it exerts its antimicrobial effects with minimal impact on the systemic microbiome or host. This targeted action makes it particularly effective in treating conditions caused by an overgrowth of gut bacteria or specific enteric pathogens.

It is commonly used for traveler's diarrhea, irritable bowel syndrome with diarrhea (IBS-D), and hepatic encephalopathy, where it reduces ammonia-producing bacteria in the gut. By reducing the bacterial load in the intestines, rifaximin helps to alleviate symptoms such as diarrhea, abdominal pain, and bloating, while minimizing the risk of systemic side effects.

Uses

• Treatment of traveler's diarrhea
• Management of irritable bowel syndrome with diarrhea (IBS-D)
• Reduction of risk of overt hepatic encephalopathy recurrence
• Treatment of small intestinal bacterial overgrowth (SIBO)

Directions For Use

Take one tablet two or three times daily, as directed by your physician. Can be taken with or without food.

Benefits

• Targeted action within the gut lumen
• Minimal systemic absorption and side effects
• Effective against a broad spectrum of gut bacteria
• Reduces symptoms of diarrhea and abdominal discomfort
• Improves quality of life for IBS-D patients
• Helps manage hepatic encephalopathy

Side Effects

• Nausea
• Abdominal pain
• Flatulence
• Headache
• Dizziness
• Peripheral edema
• Fatigue
• Constipation
• Diarrhea (paradoxical)
• Rash
• Muscle spasms
• Dyspepsia

Safety Measures

• Alcohol - Avoid or limit alcohol consumption as it can irritate the gut and potentially worsen gastrointestinal symptoms, which may interfere with treatment.
• Pregnancy - Use during pregnancy is generally not recommended unless clearly necessary, as animal studies have shown some risk. Consult your doctor.
• Breastfeeding - It is unknown if rifaximin is excreted in human milk; therefore, caution is advised. Consult your doctor before use.
• Liver - Use with caution in patients with severe liver impairment, particularly in hepatic encephalopathy, as systemic exposure may be slightly increased.
• Kidney - Generally considered safe for use in patients with kidney conditions due to minimal systemic absorption. No dose adjustment typically needed.
• Lung - No specific contraindications related to lung conditions, but always inform your doctor about all existing health issues.

Disclaimer

MedEHub is committed to delivering reliable, expert-reviewd information to help consumers make informed health decisions. However, the content provided on this website is for informational purposes only and is not intended to replace professional medical advice, diagnosis or treatment.

Always consult your doctor for any medical concerns, and discuss your questions about health conditions or medications with a qualified healthcare professional. Do not ignore or delay seeking professional medical advice based on information found on Med E Hub.

Our goal is to complement, not replace, the essential doctor-patient relationship.