About
Leflunomide is an immunomodulatory drug classified as a disease-modifying antirheumatic drug (DMARD). It works by inhibiting pyrimidine synthesis, thereby reducing the proliferation of activated lymphocytes, which are key players in the inflammatory processes of autoimmune diseases. It is primarily indicated for the treatment of active rheumatoid arthritis and psoriatic arthritis. By modulating the immune response, leflunomide helps to reduce inflammation, alleviate pain, and prevent progressive joint damage, ultimately improving physical function and quality of life for patients. Its therapeutic effects typically become evident after several weeks to months of consistent use, requiring ongoing monitoring for efficacy and potential adverse effects, particularly liver function. This medication is crucial for slowing disease progression and preserving joint integrity in chronic autoimmune conditions, often used when other DMARDs are insufficient or not tolerated.
Uses
- Treatment of active rheumatoid arthritis.
- Management of active psoriatic arthritis.
- Reduction of joint inflammation and pain.
- Slowing the progression of structural joint damage.
Directions For Use
Take this medication orally, usually once daily, with or without food, as directed by your physician.
Benefits
- Reduces inflammation in affected joints.
- Slows the progression of joint damage.
- Improves physical function and mobility.
- Alleviates pain associated with arthritis.
- Offers long-term disease control for chronic conditions.
- Available as a convenient oral tablet.
Side Effects
- Nausea
- Diarrhea
- Abdominal pain
- Liver enzyme elevation
- Hair thinning or loss
- Skin rash
- Hypertension
- Headache
- Dizziness
- Paresthesia (tingling/numbness)
- Leukopenia (low white blood cell count)
- Increased risk of infections
Safety Measures
- Alcohol - Avoid or limit alcohol consumption due to an increased risk of liver toxicity when combined with leflunomide.
- Pregnancy - This medication is highly teratogenic and contraindicated in pregnancy. Effective contraception is essential during treatment and for an extended period after discontinuation.
- Breastfeeding - Leflunomide is excreted into breast milk and can cause serious adverse effects in infants. Breastfeeding is not recommended during treatment.
- Liver - Use with extreme caution or avoid in patients with pre-existing liver disease or impaired liver function, as it can cause severe hepatotoxicity. Regular liver function monitoring is crucial.
- Kidney - Use with caution in patients with renal impairment. Dosage adjustments may be necessary, and close monitoring is advised.
- Lung - Rare but serious cases of interstitial lung disease have been reported. Monitor for new or worsening respiratory symptoms.
Disclaimer
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Always consult your doctor for any medical concerns, and discuss your questions about health conditions or medications with a qualified healthcare professional. Do not ignore or delay seeking professional medical advice based on information found on Med E Hub.
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