About

Grastim Injection contains filgrastim, a recombinant human granulocyte-colony stimulating factor (G-CSF). G-CSF is a naturally occurring cytokine that regulates the production and release of neutrophils from the bone marrow. Filgrastim works by binding to specific receptors on hematopoietic stem cells and progenitor cells, stimulating their proliferation, differentiation, and maturation into functional neutrophils. It also enhances the phagocytic activity and cytotoxic function of mature neutrophils. The primary therapeutic application of Grastim is to increase neutrophil counts in patients suffering from neutropenia, a condition characterized by abnormally low levels of neutrophils, which are crucial for fighting bacterial and fungal infections. This is particularly important in patients undergoing chemotherapy, bone marrow transplantation, or those with severe chronic neutropenia, where the risk of life-threatening infections is significantly elevated. By boosting neutrophil production, Grastim helps to reduce the incidence and duration of febrile neutropenia and associated complications.

Uses

Treatment of chemotherapy-induced neutropenia.
Mobilization of peripheral blood progenitor cells.
Management of severe chronic neutropenia.
Neutropenia following bone marrow transplantation.

Directions For Use

Administer as a subcutaneous injection or intravenous infusion, typically once daily, as directed by a healthcare professional. Dosage is based on body weight and clinical indication.

Benefits

Increases neutrophil counts effectively.
Reduces the incidence of febrile neutropenia.
Shortens the duration of neutropenia.
Decreases the risk of serious infections.
Supports bone marrow recovery post-chemotherapy.
Enhances immune system function.

Side Effects

Bone pain
Muscle pain
Headache
Fatigue
Nausea
Vomiting
Diarrhea
Alopecia
Injection site reactions
Splenomegaly (rare)
Allergic reactions (rare)
Thrombocytopenia (rare)

Safety Measures

Alcohol - No direct interaction; however, alcohol may exacerbate general fatigue or nausea.
Pregnancy - Use only if clearly needed and potential benefits outweigh risks; consult a healthcare professional.
Breastfeeding - Caution is advised; it is unknown if filgrastim is excreted in human milk.
Liver - No specific dose adjustment is typically required for liver impairment.
Kidney - No specific dose adjustment is typically required for kidney impairment.
Lung - Rare cases of acute respiratory distress syndrome (ARDS) have been reported; monitor for pulmonary symptoms.

Disclaimer

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