Human Mixtard 40IU 10 ml vial

About

Human Mixtard 40IU 10 ml vial is a biphasic insulin preparation containing a precise mixture of soluble human insulin (rapid-acting) and isophane human insulin (intermediate-acting). This formulation is specifically designed to provide both a rapid onset of action to effectively cover post-meal glucose spikes and a prolonged duration of action to maintain basal glucose control throughout the day. The 40 IU/ml concentration indicates that each milliliter of the solution contains 40 International Units of insulin. It is primarily used in the comprehensive management of diabetes mellitus, encompassing both Type 1 and Type 2, where the body's endogenous insulin production is either insufficient or entirely absent.

The biphasic nature of Human Mixtard allows for a more physiological insulin profile, aiming to mimic the body's natural insulin release patterns to some extent. Patients are typically instructed to administer this insulin subcutaneously, usually 15-30 minutes before a meal. Alongside insulin therapy, careful monitoring of blood glucose levels, strict adherence to dietary recommendations, and regular physical activity are crucial components of effective diabetes management. Proper injection technique and storage are paramount for ensuring the medication's efficacy and patient safety.

Uses

• Management of Type 1 Diabetes Mellitus.
• Management of Type 2 Diabetes Mellitus.
• Control of hyperglycemia in diabetic patients.
• To achieve stable blood glucose levels throughout the day.

Directions For Use

Administer subcutaneously as directed by your doctor, usually before meals. Rotate injection sites.

Benefits

• Provides both rapid and intermediate insulin action.
• Helps control post-meal blood glucose.
• Maintains basal glucose levels.
• Reduces overall HbA1c levels.
• Improves glycemic control in diabetic patients.
• Widely available and cost-effective.

Side Effects

• Hypoglycemia (low blood sugar)
• Injection site reactions (pain, redness, swelling)
• Lipodystrophy (fat changes at injection site)
• Weight gain
• Allergic reactions (rare)
• Peripheral edema
• Pruritus (itching)
• Rash
• Urticaria (hives)
• Blurred vision (temporary)
• Diabetic retinopathy worsening (initial)
• Diabetic neuropathy worsening (initial)

Safety Measures

• Alcohol - Avoid or limit alcohol, as it can increase the risk of hypoglycemia, especially when taken on an empty stomach.
• Pregnancy - Essential for managing gestational diabetes or pre-existing diabetes. Close monitoring and dose adjustments are crucial.
• Breastfeeding - Generally considered safe during breastfeeding, but dose adjustments may be needed.
• Liver - Use with caution in liver impairment; insulin requirements may change due to altered glucose metabolism.
• Kidney - Use with caution in kidney impairment; insulin requirements may decrease due to reduced insulin clearance.
• Lung - No specific contraindications, but monitor for infections which can affect blood sugar control.

Disclaimer

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