ITRAGEN 200 TAB 8

About

Itragen 200 Tab, containing itraconazole, is a broad-spectrum triazole antifungal agent used to treat various fungal infections. It works by inhibiting the fungal cytochrome P450-dependent enzyme lanosterol 14α-demethylase, which is essential for ergosterol synthesis. Ergosterol is a vital component of the fungal cell membrane, and its depletion leads to increased cell membrane permeability, leakage of cellular contents, and ultimately fungal cell death. This mechanism makes itraconazole effective against a wide range of dermatophytes, yeasts, and molds, including those causing systemic mycoses. Its lipophilic and keratinophilic properties allow it to concentrate in tissues like skin, nails, and vaginal mucosa, providing sustained therapeutic levels.

Itraconazole is particularly useful for infections that are resistant to other antifungals or for patients who cannot tolerate other treatments. It is available in various formulations, including capsules, oral solution, and intravenous solution, allowing for flexible dosing regimens depending on the type and severity of the fungal infection. Due to its complex pharmacokinetics and potential for drug interactions, careful patient selection and monitoring are crucial during treatment.

Uses

• Treatment of superficial fungal infections (e.g., onychomycosis, tinea corporis).
• Management of systemic fungal infections (e.g., histoplasmosis, blastomycosis, aspergillosis).
• Treatment of oropharyngeal and esophageal candidiasis.
• Prophylaxis of fungal infections in immunocompromised patients.

Directions For Use

Take as directed by your physician, usually with a full meal to enhance absorption. Do not crush or chew tablets.

Benefits

• Broad-spectrum antifungal activity.
• Effective against various dermatophytes, yeasts, and molds.
• Penetrates well into skin, nails, and other tissues.
• Available in multiple formulations for diverse needs.
• Useful for both superficial and systemic infections.
• Can be used for prophylaxis in at-risk individuals.

Side Effects

• Nausea
• Abdominal pain
• Diarrhea
• Headache
• Dizziness
• Rash
• Elevated liver enzymes
• Peripheral neuropathy
• Congestive heart failure (rare)
• Hypokalemia
• Edema
• Hypertension

Safety Measures

• Alcohol - Avoid alcohol consumption as it may increase the risk of liver side effects and can interact with the medication.
• Pregnancy - Generally contraindicated in pregnancy due to potential teratogenic effects; use only if the potential benefit justifies the potential risk to the fetus.
• Breastfeeding - Itraconazole is excreted in breast milk; breastfeeding is generally not recommended during treatment.
• Liver - Use with caution in patients with hepatic impairment; monitor liver function tests regularly.
• Kidney - Use with caution in patients with renal impairment; dose adjustment may be necessary.
• Lung - Use with caution in patients with a history of congestive heart failure or other lung conditions, as it can exacerbate these conditions.

Disclaimer

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