About
Cabozantinib is a potent, orally administered small molecule tyrosine kinase inhibitor (TKI) that targets a broad spectrum of receptor tyrosine kinases crucial for tumor growth, angiogenesis, and metastasis. Key targets include MET, VEGFR1, 2, and 3, AXL, and RET. By simultaneously inhibiting these multiple pathways, cabozantinib effectively disrupts the signaling cascades that drive cancer cell proliferation, survival, and migration, thereby impeding tumor progression and vascularization. This multi-targeted approach makes it a valuable therapeutic option for various advanced malignancies, including medullary thyroid cancer, advanced renal cell carcinoma, and hepatocellular carcinoma, where these pathways are often dysregulated. While highly effective, its broad kinase inhibition profile also contributes to a diverse range of potential side effects, such as hypertension, diarrhea, and hand-foot syndrome, requiring careful patient selection and proactive management to optimize treatment outcomes.
Uses
- Treatment of medullary thyroid cancer.
- Management of advanced renal cell carcinoma.
- Therapy for hepatocellular carcinoma.
- Treatment of differentiated thyroid cancer.
Directions For Use
Take orally once daily on an empty stomach (at least 2 hours after and 1 hour before food).
Benefits
- Targets multiple cancer pathways.
- Effective against various advanced cancers.
- Inhibits tumor growth and metastasis.
- Reduces angiogenesis in tumors.
- Oral administration for convenience.
- Improves progression-free survival.
Side Effects
- Diarrhea
- Fatigue
- Nausea
- Vomiting
- Decreased appetite
- Hypertension (high blood pressure)
- Hand-foot syndrome
- Weight loss
- Abdominal pain
- Dysphonia (hoarseness)
- Hypothyroidism
- Proteinuria
Safety Measures
- Alcohol - Avoid alcohol as it may exacerbate gastrointestinal side effects.
- Pregnancy - Contraindicated; can cause fetal harm. Use effective contraception.
- Breastfeeding - Contraindicated; unknown if excreted in human milk, but potential for serious adverse reactions.
- Liver - Use with caution in moderate to severe hepatic impairment; dose adjustment may be needed.
- Kidney - Use with caution in severe renal impairment; monitor closely.
- Lung - Rare cases of pneumonitis reported; monitor for new or worsening respiratory symptoms.
Disclaimer
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Always consult your doctor for any medical concerns, and discuss your questions about health conditions or medications with a qualified healthcare professional. Do not ignore or delay seeking professional medical advice based on information found on Med E Hub.
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| Shop Location | Assam, India |
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