About
Leuprolide is a synthetic analogue of gonadotropin-releasing hormone (GnRH), functioning as a potent GnRH receptor agonist. Its therapeutic effect stems from a biphasic action: an initial transient stimulation of pituitary GnRH receptors, followed by a sustained desensitization and downregulation of these receptors. This desensitization leads to a profound and continuous suppression of pituitary gonadotropin release, specifically luteinizing hormone (LH) and follicle-stimulating hormone (FSH). Consequently, there is a significant reduction in the production of gonadal steroids, such as testosterone in males and estrogen in females. This pharmacological castration effect is highly valuable in managing various hormone-sensitive conditions, including advanced prostate cancer, endometriosis, uterine fibroids, and central precocious puberty, by effectively lowering sex hormone levels to therapeutic targets.
Uses
- Treatment of advanced prostate cancer.
- Management of endometriosis.
- Treatment of uterine fibroids (leiomyoma).
- Management of central precocious puberty.
Directions For Use
Administered via subcutaneous or intramuscular injection by a healthcare professional, typically on a monthly or quarterly basis.
Benefits
- Effectively reduces testosterone levels in prostate cancer.
- Alleviates pain and reduces lesion size in endometriosis.
- Shrinks uterine fibroids and reduces associated symptoms.
- Halts progression of precocious puberty.
- Provides long-acting hormonal suppression.
- Offers a non-surgical option for hormone-dependent conditions.
Side Effects
- Hot flashes
- Injection site reactions (pain, redness)
- Fatigue
- Headache
- Nausea
- Bone pain (initial flare-up in prostate cancer)
- Decreased libido
- Erectile dysfunction (males)
- Vaginal dryness (females)
- Mood changes
- Weight changes
- Osteoporosis (long-term use)
Safety Measures
- Alcohol - No direct interaction with alcohol, but excessive intake may worsen fatigue or mood changes.
- Pregnancy - Contraindicated in pregnancy due to risk of fetal harm; ensure non-pregnant status before initiation.
- Breastfeeding - Not recommended during breastfeeding as it is unknown if leuprolide is excreted in human milk.
- Liver - Use with caution in patients with liver impairment; monitor liver function tests periodically.
- Kidney - Generally safe for use in patients with renal impairment; no dose adjustment typically required.
- Lung - No specific precautions for lung conditions, but monitor for any new or worsening respiratory symptoms.
Disclaimer
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| Shop Location | Assam, India |
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