About
Leuprolide is a synthetic nonapeptide analog of naturally occurring gonadotropin-releasing hormone (GnRH). Its primary mechanism of action involves initially stimulating, then subsequently desensitizing and downregulating, GnRH receptors in the anterior pituitary gland. This biphasic effect leads to a profound and sustained suppression of pituitary gonadotropin secretion, specifically luteinizing hormone (LH) and follicle-stimulating hormone (FSH). Consequently, the production of sex steroids, such as testosterone in males and estrogen in females, is significantly reduced to castrate levels. This hormonal suppression is therapeutically beneficial in managing various hormone-dependent conditions, including advanced prostate cancer, endometriosis, uterine fibroids, and central precocious puberty. The continuous administration of leuprolide effectively mitigates the growth and progression of these conditions by removing the hormonal stimulus they rely upon.
Uses
- Prostate cancer
- Endometriosis
- Uterine fibroids
- Precocious puberty
Directions For Use
Administer as a subcutaneous or intramuscular injection, typically once a month or every few months, as directed by your physician.
Benefits
- Effective in hormone-sensitive cancers
- Reduces pain and symptoms in endometriosis
- Shrinks uterine fibroids
- Manages precocious puberty
- Long-acting formulations available
- Non-surgical treatment option
Side Effects
- Hot flashes
- Headache
- Injection site reactions
- Bone pain (initial flare)
- Decreased libido
- Vaginal dryness
- Mood changes
- Weight changes
- Bone density loss
- Muscle weakness
- Testicular atrophy
- Ovarian cysts (initial flare)
Safety Measures
- Alcohol - No specific contraindication, but excessive alcohol may worsen hot flashes or mood changes in some individuals.
- Pregnancy - Contraindicated in pregnancy due to the risk of fetal harm and potential for miscarriage.
- Breastfeeding - Not recommended during breastfeeding as it may interfere with milk production and hormone balance.
- Liver - Use with caution in patients with liver impairment; monitor liver function tests.
- Kidney - No specific dose adjustment required for renal impairment, but monitor for fluid retention.
- Lung - Generally no direct impact on lung function; use with caution in patients with severe respiratory conditions if systemic effects are a concern.
Disclaimer
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Always consult your doctor for any medical concerns, and discuss your questions about health conditions or medications with a qualified healthcare professional. Do not ignore or delay seeking professional medical advice based on information found on Med E Hub.
Our goal is to complement, not replace, the essential doctor-patient relationship.
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| Shop Location | Assam, India |
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