Leutero 50mg Injection

About

Leuprolide is a synthetic analog of gonadotropin-releasing hormone (GnRH), functioning as a potent GnRH receptor agonist. Upon initial administration, it paradoxically causes a transient surge in the secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the pituitary gland, leading to a temporary increase in gonadal steroid levels. However, with continuous and sustained administration, leuprolide induces desensitization and downregulation of the pituitary GnRH receptors. This sustained suppression effectively inhibits the release of LH and FSH, consequently leading to a profound and consistent reduction in gonadal steroid production—specifically, testosterone in males and estrogen in females. This state, often referred to as "medical castration," is therapeutically utilized in the management of various hormone-sensitive conditions, providing a non-surgical approach to hormone suppression.

Uses

• Prostate cancer (palliative treatment)
• Endometriosis
• Uterine fibroids (leiomyoma)
• Precocious puberty

Directions For Use

Administered via subcutaneous or intramuscular injection by a healthcare professional. Dosage and frequency vary based on the condition being treated.

Benefits

• Effective in reducing sex hormone levels
• Manages hormone-sensitive cancers
• Alleviates symptoms of endometriosis
• Reduces uterine fibroid size
• Delays puberty progression
• Available in various depot formulations for extended action

Side Effects

• Hot flashes/sweats
• Decreased libido
• Erectile dysfunction (males)
• Vaginal dryness (females)
• Bone density loss (long-term use)
• Injection site reactions (pain, redness)
• Headache
• Nausea/vomiting
• Fatigue
• Mood changes/depression
• Weight changes
• Initial "flare-up" of symptoms

Safety Measures

• Alcohol - No specific contraindication, but excessive alcohol may exacerbate hot flashes or mood changes.
• Pregnancy - Contraindicated in pregnancy due to risk of fetal harm and potential for miscarriage.
• Breastfeeding - Not recommended during breastfeeding as it is unknown if it passes into breast milk and could affect infant hormones.
• Liver - Use with caution in patients with liver impairment; no specific dose adjustment usually required.
• Kidney - Use with caution in patients with renal impairment; no specific dose adjustment usually required.
• Lung - Generally safe for lung conditions; no specific precautions related to pulmonary function.

Disclaimer

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