LODOZ 5MG TAB

About

Bisoprolol Fumarate is a highly selective beta-1 adrenergic receptor blocker, commonly known as a beta-blocker. It works by blocking the effects of adrenaline on the heart, leading to a slower heart rate and reduced force of contraction. This action decreases the heart's workload and oxygen demand, which is beneficial in conditions like angina and heart failure.

In hypertension, Bisoprolol helps to lower blood pressure by reducing cardiac output and inhibiting the release of renin from the kidneys. Its cardioselective nature at lower doses means it has less impact on beta-2 receptors in the lungs, making it generally better tolerated by patients with mild to moderate respiratory conditions compared to non-selective beta-blockers.

Uses

• Treatment of essential hypertension.
• Management of chronic stable angina pectoris.
• Treatment of stable chronic heart failure with reduced ejection fraction.
• Reduction of cardiovascular mortality and morbidity.

Directions For Use

Take one tablet orally once daily, preferably in the morning, with or without food. Do not crush or chew the tablet.

Benefits

• Effective in lowering blood pressure.
• Reduces frequency and severity of angina attacks.
• Improves symptoms and survival in heart failure.
• Slows heart rate and reduces cardiac workload.
• Cardioselective at lower doses.
• Once-daily dosing for convenience.

Side Effects

• Fatigue
• Dizziness
• Headache
• Bradycardia (slow heart rate)
• Cold extremities
• Nausea
• Diarrhea or constipation
• Insomnia
• Erectile dysfunction
• Bronchospasm (rare, especially at higher doses)
• Hypotension
• Worsening of heart failure (initial stages)

Safety Measures

• Alcohol - Alcohol can enhance the blood pressure-lowering effect and increase dizziness. Avoid or limit consumption.
• Pregnancy - Use only if the potential benefit justifies the potential risk to the fetus. May cause bradycardia, hypoglycemia, and respiratory depression in the neonate.
• Breastfeeding - Bisoprolol is excreted in breast milk. Not recommended during breastfeeding. Consult a doctor.
• Liver - Use with caution in patients with liver impairment; dosage adjustments may be necessary.
• Kidney - Dosage adjustments are required in patients with severe renal impairment.
• Lung - Contraindicated in severe asthma, severe COPD, or other severe bronchospastic conditions. Use with extreme caution in mild to moderate cases.

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