About
Losavert 16 mg Tablets contain Losartan, a highly selective angiotensin II receptor blocker (ARB) that plays a pivotal role in the management of cardiovascular conditions. Losartan exerts its therapeutic effects by specifically blocking the binding of angiotensin II to the AT1 receptor. This receptor is widely distributed in various tissues, including vascular smooth muscle, the adrenal glands, and the kidneys, where angiotensin II typically mediates potent vasoconstriction, aldosterone secretion, and cellular proliferation.
By antagonizing the AT1 receptor, Losartan effectively prevents these detrimental actions, leading to significant vasodilation, a reduction in systemic vascular resistance, and a decrease in blood pressure. Furthermore, it mitigates sodium and water retention, contributing to its antihypertensive effects. This mechanism not only provides effective blood pressure control but also offers organ protection, particularly in conditions such as diabetic nephropathy, by reducing intraglomerular pressure and proteinuria.
Uses
- Treatment of essential hypertension
- Reduction of the risk of stroke in patients with hypertension and left ventricular hypertrophy
- Treatment of diabetic nephropathy in type 2 diabetes
- Management of heart failure (off-label or specific indications)
Directions For Use
Take one tablet orally once daily, with or without food, as prescribed by your doctor.
Benefits
- Effective blood pressure control
- Reduces risk of cardiovascular events
- Protects kidneys in diabetic patients
- Well-tolerated with fewer cough side effects than ACE inhibitors
- Once-daily dosing convenience
- Helps manage heart failure symptoms
Side Effects
- Dizziness
- Fatigue
- Hypotension
- Hyperkalemia
- Renal dysfunction
- Back pain
- Upper respiratory infection
- Diarrhea
- Nausea
- Headache
- Cough (less common than ACEIs)
- Angioedema (rare)
Safety Measures
- Alcohol - Avoid or limit alcohol as it can further lower blood pressure and increase dizziness.
- Pregnancy - Contraindicated in the second and third trimesters due to fetal harm; consult a doctor immediately.
- Breastfeeding - Not recommended; consult a healthcare professional as it may pass into breast milk.
- Liver - Use with caution in patients with hepatic impairment; dosage adjustment may be necessary.
- Kidney - Use with caution in patients with renal artery stenosis or severe renal impairment; monitor kidney function.
- Lung - Generally safe for use in patients with lung conditions; does not typically cause cough like ACE inhibitors.
Disclaimer
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Always consult your doctor for any medical concerns, and discuss your questions about health conditions or medications with a qualified healthcare professional. Do not ignore or delay seeking professional medical advice based on information found on Med E Hub.
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| Shop Location | Assam, India |
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