Lupride Depot 11.25mg Injection

About

Leuprolide is a synthetic gonadotropin-releasing hormone (GnRH) agonist. It works by initially stimulating, then continuously suppressing, the pituitary gland's release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This sustained suppression leads to a significant reduction in the production of sex hormones, specifically testosterone in males and estrogen in females, effectively creating a "medical castration" effect. This mechanism is crucial in managing hormone-sensitive conditions.

The "Depot" formulation indicates a sustained-release preparation, allowing for less frequent administration, typically once a month or every few months, depending on the specific dosage. This prolonged action ensures consistent hormone suppression, which is vital for the therapeutic efficacy in conditions requiring long-term hormonal manipulation. The initial transient increase in hormone levels, known as a "flare-up," is a characteristic effect before the sustained suppression takes hold.

Uses

• Treatment of prostate cancer.
• Management of endometriosis.
• Treatment of uterine fibroids.
• Central precocious puberty.

Directions For Use

Administer via subcutaneous or intramuscular injection by a healthcare professional. Follow the prescribed dosing schedule strictly.

Benefits

• Effectively reduces sex hormone levels.
• Provides sustained therapeutic effect with depot formulation.
• Helps manage hormone-sensitive cancers.
• Alleviates symptoms of endometriosis and fibroids.
• Can halt progression of precocious puberty.
• Offers a non-surgical option for certain conditions.

Side Effects

• Hot flashes
• Sweating
• Headache
• Nausea/Vomiting
• Injection site reactions (pain, redness)
• Bone density loss (long-term use)
• Mood changes/Depression
• Fatigue
• Decreased libido
• Weight changes
• Muscle weakness
• Joint pain

Safety Measures

• Alcohol - No specific interaction, but excessive alcohol may worsen hot flashes or mood changes.
• Pregnancy - Contraindicated in pregnancy due to risk of fetal harm; ensure non-pregnant status before use.
• Breastfeeding - Not recommended during breastfeeding; potential for adverse effects on the infant.
• Liver - Use with caution in patients with liver impairment; monitor liver function.
• Kidney - Generally safe, but caution in severe renal impairment; no dose adjustment typically needed.
• Lung - No direct lung effects; however, monitor for any new or worsening respiratory symptoms.

Disclaimer

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