About
These medications are synthetic analogues of gonadotropin-releasing hormone (GnRH), designed to modulate the endocrine system. Initially, they transiently stimulate GnRH receptors in the pituitary gland, leading to a brief surge in gonadotropin (LH and FSH) release. However, continuous administration subsequently desensitizes and downregulates these receptors, resulting in a profound and sustained suppression of LH and FSH secretion. This suppression ultimately leads to a significant reduction in the production of gonadal steroids, specifically testosterone in males and estrogen in females. This therapeutic effect is strategically employed in the management of various hormone-sensitive conditions, including advanced prostate cancer, endometriosis, uterine fibroids, and central precocious puberty, where the reduction of sex hormone levels is crucial for disease control and symptom alleviation.
Uses
- Treatment of advanced prostate cancer.
- Management of endometriosis.
- Pre-operative thinning of the endometrium for uterine fibroids.
- Treatment of central precocious puberty.
Directions For Use
Administer as a subcutaneous or intramuscular injection, typically once a month or every three months, as directed by your physician.
Benefits
- Effective in reducing sex hormone levels.
- Manages symptoms of hormone-sensitive cancers and conditions.
- Offers long-acting formulations for convenience.
- Can improve quality of life for patients with chronic conditions.
- Reduces tumor growth in prostate cancer.
- Alleviates pain and symptoms associated with endometriosis.
Side Effects
- Hot flashes
- Sweating
- Headache
- Nausea
- Injection site reactions (pain, redness)
- Fatigue
- Mood changes, depression
- Decreased libido
- Bone density loss (long-term use)
- Weight gain
- Muscle weakness
- Vaginal dryness (in women)
Safety Measures
- Alcohol - No specific contraindication with alcohol, but excessive alcohol intake may exacerbate hot flashes or mood changes.
- Pregnancy - Contraindicated in pregnancy due to the risk of fetal harm. Effective contraception must be used during treatment.
- Breastfeeding - Not recommended during breastfeeding due to potential for adverse effects on the infant and suppression of lactation.
- Liver - Use with caution in patients with liver impairment. Monitor liver function tests periodically.
- Kidney - Generally considered safe in patients with kidney conditions, as it is primarily metabolized by peptidases. No specific dosage adjustment usually required.
- Lung - No specific contraindications or significant interactions with lung conditions. Use as directed.
Disclaimer
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Always consult your doctor for any medical concerns, and discuss your questions about health conditions or medications with a qualified healthcare professional. Do not ignore or delay seeking professional medical advice based on information found on Med E Hub.
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| Shop Location | Assam, India |
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