Luprova 3.75mg Injection

About

Luprova, which contains Leuprolide, is a synthetic analog of gonadotropin-releasing hormone (GnRH) and functions as a GnRH agonist. Its therapeutic action involves an initial transient stimulation of the pituitary gland, leading to a surge in luteinizing hormone (LH) and follicle-stimulating hormone (FSH) release. However, with continuous administration, it causes a desensitization and downregulation of pituitary GnRH receptors, resulting in a profound and sustained suppression of LH and FSH production. This ultimately leads to a significant reduction in circulating sex hormone levels—testosterone in males and estrogen in females. In men, Luprova is a cornerstone therapy for advanced prostate cancer. In women, it is effectively used to manage endometriosis, reduce the size of uterine fibroids, and is occasionally employed in controlled ovarian stimulation for assisted reproductive technologies. For pediatric patients, it is vital in the management of central precocious puberty. The sustained hormonal suppression achieved by Luprova effectively creates a reversible medical castration or menopause-like state, which alleviates symptoms and slows the progression of these hormone-dependent conditions.

Uses

• Treatment of advanced prostate cancer.
• Management of endometriosis.
• Treatment of uterine fibroids.
• Management of central precocious puberty.

Directions For Use

Administer via subcutaneous or intramuscular injection as directed by a healthcare professional. Dosage and frequency vary based on the condition being treated.

Benefits

• Effectively suppresses sex hormone levels.
• Reduces tumor growth in prostate cancer.
• Alleviates pain and symptoms of endometriosis.
• Shrinks uterine fibroids.
• Manages precocious puberty in children.
• Available in various formulations for different dosing schedules.

Side Effects

• Hot flashes
• Headache
• Nausea/Vomiting
• Injection site reactions (pain, redness)
• Fatigue
• Bone pain (initial flare in prostate cancer)
• Decreased libido
• Mood changes/Depression
• Bone density loss (long-term use)
• Weight gain
• Edema
• Testicular atrophy (men)

Safety Measures

• Alcohol - No specific contraindication, but excessive alcohol may exacerbate mood changes or bone density issues.
• Pregnancy - Contraindicated; it can cause fetal harm. Ensure non-pregnant status before starting treatment.
• Breastfeeding - Not recommended; it is unknown if it passes into breast milk, but potential hormonal effects on the infant are a concern.
• Liver - Use with caution in patients with liver impairment; monitor liver function tests periodically.
• Kidney - Generally safe for use in patients with kidney conditions; no specific dose adjustment is usually required.
• Lung - No direct impact on lung function, but monitor for any new or worsening respiratory symptoms, especially in patients with pre-existing conditions.

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