MET XL 3D 25/6.25 TAB 10 S

About

MET XL 3D 25/6.25 is a triple-combination medication designed for the effective management of severe or resistant essential hypertension. It integrates metoprolol succinate extended-release, a cardioselective beta-1 adrenergic blocker; hydrochlorothiazide, a thiazide diuretic; and an angiotensin II receptor blocker (ARB). This comprehensive formulation targets distinct yet complementary pathways involved in blood pressure regulation. Metoprolol reduces heart rate and myocardial contractility, hydrochlorothiazide promotes the excretion of sodium and water, thereby reducing blood volume, and the ARB blocks the vasoconstrictive and aldosterone-secreting effects of angiotensin II. The synergistic action of these three agents provides potent and sustained blood pressure control, significantly reducing the risk of major cardiovascular events such as stroke and myocardial infarction. This combination is particularly valuable for patients who require multiple antihypertensive agents to achieve their target blood pressure goals, offering a simplified regimen and enhanced therapeutic outcomes.

Uses

• Treatment of essential hypertension, especially severe or resistant cases.
• When blood pressure is not adequately controlled by dual therapy.
• To reduce the risk of cardiovascular events in high-risk patients.
• For patients requiring multiple antihypertensive agents.

Directions For Use

Take one tablet orally once daily, preferably at the same time each day. It can be taken with or without food.

Benefits

• Provides powerful triple-action blood pressure reduction.
• Offers comprehensive control for resistant hypertension.
• Reduces the risk of major cardiovascular events.
• Ensures sustained blood pressure control over 24 hours.
• Simplifies medication regimen, improving adherence.
• Targets multiple physiological mechanisms of hypertension.

Side Effects

• Dizziness, lightheadedness, or fatigue
• Hypotension (low blood pressure)
• Hyperkalemia (high potassium, due to ARB)
• Hypokalemia (low potassium, due to diuretic)
• Nausea, vomiting, or diarrhea
• Headache
• Cough (less common than ACE inhibitors)
• Muscle cramps or weakness
• Increased uric acid levels
• Renal dysfunction
• Bradycardia
• Photosensitivity (due to HCTZ)

Safety Measures

• Alcohol - Avoid or limit alcohol consumption as it can exacerbate hypotensive effects and increase the risk of dizziness.
• Pregnancy - Contraindicated in the second and third trimesters due to the ARB component's risk of fetal harm. Use with extreme caution in the first trimester.
• Breastfeeding - All components are excreted in breast milk. Not recommended during breastfeeding due to potential adverse effects on the infant.
• Liver - Use with caution in patients with severe liver impairment as metabolism of all components may be affected, requiring dose adjustment.
• Kidney - Use with extreme caution in severe renal impairment or bilateral renal artery stenosis due to risk of worsening kidney function. Monitor renal function closely.
• Lung - Use with caution in patients with bronchospastic diseases like asthma, due to the metoprolol component, which may worsen respiratory symptoms.

Disclaimer

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