Myelostem 50mg Injection

About

Myelostem 50mg Injection is a recombinant human granulocyte colony-stimulating factor (G-CSF), a crucial hematopoietic growth factor. It functions by stimulating the proliferation, differentiation, and activation of neutrophil precursors within the bone marrow, leading to a significant increase in mature neutrophil counts in the peripheral blood. Neutrophils are essential white blood cells that play a vital role in the body's immune response against bacterial and fungal infections. This medication is primarily used to mitigate the risk and duration of neutropenia, a condition characterized by abnormally low neutrophil levels, which commonly occurs following myelosuppressive chemotherapy or in patients undergoing bone marrow transplantation. By enhancing neutrophil recovery, Myelostem helps reduce the incidence of febrile neutropenia and associated infectious complications, thereby improving patient safety and allowing for more consistent chemotherapy delivery.

Uses

• Chemotherapy-induced neutropenia
• Bone marrow transplantation
• Severe chronic neutropenia
• Mobilization of peripheral blood progenitor cells

Directions For Use

Administered subcutaneously or intravenously as directed by a healthcare professional. Dosage is individualized based on body weight and clinical indication.

Benefits

• Reduces incidence of febrile neutropenia.
• Shortens duration of neutropenia.
• Decreases risk of infection in immunocompromised patients.
• Facilitates dose-intensive chemotherapy regimens.
• Improves recovery after bone marrow transplant.
• Enhances mobilization of stem cells for collection.

Side Effects

• Bone pain
• Myalgia (muscle pain)
• Headache
• Fatigue
• Nausea
• Splenomegaly (enlarged spleen)
• Injection site reactions
• Thrombocytopenia (low platelet count)
• Leukocytosis (high white blood cell count)
• Allergic reactions
• Acute respiratory distress syndrome (rare)
• Glomerulonephritis (rare)

Safety Measures

• Alcohol - No specific contraindication, but excessive alcohol may worsen general health or mask symptoms of underlying conditions.
• Pregnancy - Use only if clearly needed; potential risks to the fetus should be carefully weighed against maternal benefits.
• Breastfeeding - Exercise caution; it is unknown if the drug is excreted in human milk. Consult a healthcare professional.
• Liver - No specific dose adjustment required for liver impairment, but monitor overall health and liver function if concerns arise.
• Kidney - No specific dose adjustment required for renal impairment, but monitor renal function, especially in patients with pre-existing conditions.
• Lung - Monitor for pulmonary adverse reactions, such as interstitial lung disease or acute respiratory distress syndrome, particularly in patients with pre-existing lung conditions.

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