Nab Taxhal 100mg Injection

About

Nab Taxhal 100mg Injection, containing nanoparticle albumin-bound paclitaxel, is an antineoplastic agent primarily used in the treatment of various solid tumors. This formulation utilizes albumin to deliver paclitaxel, a microtubule inhibitor, directly to tumor cells, potentially enhancing efficacy and reducing certain toxicities associated with conventional paclitaxel formulations. Paclitaxel works by stabilizing microtubules, preventing their depolymerization, which ultimately arrests cell division in the G2/M phase and induces apoptosis in rapidly dividing cancer cells. Its mechanism disrupts the dynamic equilibrium of the microtubule system, essential for mitotic and interphase cellular functions.

The albumin-bound technology allows for intravenous administration without the need for solvents like Cremophor EL, which can cause severe hypersensitivity reactions. This leads to a more favorable safety profile for some patients and allows for higher doses of paclitaxel to be delivered. It is a critical component in multi-modal cancer therapy, often used in combination with other chemotherapeutic agents or radiation therapy, depending on the specific cancer type and stage.

Uses

• Metastatic breast cancer
• Non-small cell lung cancer
• Pancreatic adenocarcinoma
• Advanced ovarian cancer

Directions For Use

Administered intravenously by a qualified healthcare professional. Dosage and frequency are determined by the patient's condition and treatment protocol.

Benefits

• Effective against various solid tumors
• Improved drug delivery to tumor cells
• Reduced risk of hypersensitivity reactions
• Avoids solvent-related toxicities
• Potential for higher paclitaxel dosing
• Part of comprehensive cancer treatment

Side Effects

• Bone marrow suppression (neutropenia, anemia, thrombocytopenia)
• Peripheral neuropathy (numbness, tingling)
• Alopecia (hair loss)
• Nausea and vomiting
• Fatigue and weakness
• Arthralgia and myalgia (joint and muscle pain)
• Mucositis (inflammation of mucous membranes)
• Hypersensitivity reactions (rare with nab-formulation)
• Infection risk due to immunosuppression
• Elevated liver enzymes
• Fluid retention (edema)
• Diarrhea or constipation

Safety Measures

• Alcohol - Avoid alcohol consumption as it can exacerbate liver toxicity and other side effects associated with chemotherapy.
• Pregnancy - Contraindicated during pregnancy due to high risk of fetal harm and teratogenicity. Effective contraception is essential.
• Breastfeeding - Not recommended during breastfeeding as the drug can pass into breast milk and harm the infant.
• Liver - Use with caution in patients with hepatic impairment; dose adjustments may be necessary. Monitor liver function closely.
• Kidney - Administer with caution in patients with renal impairment. Regular monitoring of kidney function is advised.
• Lung - Rare but serious pulmonary toxicity, including interstitial pneumonitis, can occur. Monitor for respiratory symptoms.

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