Neocarb 450mg Injection

About

Carboplatin is a platinum-based alkylating agent widely utilized in cancer chemotherapy. Its primary mechanism of action involves forming inter- and intra-strand DNA cross-links, which disrupts the normal structure and function of DNA within cancer cells. This interference prevents DNA replication and transcription, leading to cell cycle arrest and ultimately inducing apoptosis in rapidly proliferating malignant cells. Carboplatin is often administered intravenously, either as a single agent or, more commonly, in combination with other antineoplastic drugs to enhance its cytotoxic effects and broaden its spectrum of activity. Its efficacy is well-established across various solid tumors, making it a cornerstone in many oncology treatment protocols. The drug's cytotoxic effects are dose-dependent and primarily target rapidly dividing cells, including cancer cells and certain healthy cells, which accounts for its characteristic side effect profile.

Uses

• Ovarian cancer
• Non-small cell lung cancer
• Head and neck cancer
• Germ cell tumors

Directions For Use

Administered intravenously by a healthcare professional. Dosage and frequency depend on the specific cancer type, patient's body surface area, and renal function.

Benefits

• Effective against a range of solid tumors.
• Often used in combination regimens.
• Can induce remission in sensitive cancers.
• Manageable side effect profile compared to some other agents.
• Available as an intravenous formulation for precise dosing.
• Established efficacy in various treatment protocols.

Side Effects

• Nausea and vomiting
• Bone marrow suppression (myelosuppression)
• Thrombocytopenia (low platelet count)
• Leukopenia (low white blood cell count)
• Anemia (low red blood cell count)
• Peripheral neuropathy
• Ototoxicity (hearing loss)
• Hypersensitivity reactions
• Electrolyte disturbances
• Fatigue
• Hair thinning
• Mucositis

Safety Measures

• Alcohol - Avoid alcohol as it may exacerbate gastrointestinal side effects and liver toxicity.
• Pregnancy - Contraindicated in pregnancy due to severe fetal harm risk; effective contraception is essential.
• Breastfeeding - Not recommended during breastfeeding as it may pass into breast milk and harm the infant.
• Liver - Use with caution in patients with liver impairment; dose adjustments may be necessary.
• Kidney - Dose adjustment is crucial in renal impairment due to its primary excretion route; monitor kidney function closely.
• Lung - Rarely associated with interstitial lung disease; monitor for respiratory symptoms.

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