Nexavar 200mg Tablet

About

Nexavar 200mg Tablet, containing Sorafenib, is an oral multi-kinase inhibitor used in the treatment of advanced cancers. It exerts its anti-tumor effects by inhibiting both tumor cell proliferation and tumor angiogenesis. Sorafenib targets several intracellular and cell surface kinases, including Raf-1, B-Raf, VEGFR-2, VEGFR-3, PDGFR-β, c-KIT, and FLT3. By blocking these key signaling pathways, Nexavar disrupts the growth and survival of cancer cells and inhibits the formation of new blood vessels that supply tumors, thereby slowing disease progression and reducing tumor burden.

This medication is typically prescribed by oncologists for patients with specific types of advanced or metastatic cancers. Treatment with Nexavar requires careful monitoring for efficacy and potential adverse effects, which can include dermatological reactions, hypertension, and gastrointestinal issues. The dosage and duration of therapy are determined by the treating physician based on the patient's condition, response to treatment, and tolerability. Regular clinical assessments, including blood tests and imaging, are essential to optimize treatment outcomes and manage any emerging side effects effectively.

Uses

• Treatment of unresectable hepatocellular carcinoma (HCC).
• Management of advanced renal cell carcinoma (RCC).
• Therapy for differentiated thyroid carcinoma (DTC) that is refractory to radioactive iodine.
• Used in certain advanced solid tumors where specific kinase pathways are implicated.

Directions For Use

Take this tablet orally, usually twice daily, at least one hour before or two hours after a meal, as directed by your doctor. Swallow the tablets whole with water.

Benefits

• Targets multiple kinases involved in cancer growth and angiogenesis.
• Approved for specific advanced liver, kidney, and thyroid cancers.
• Can improve overall and progression-free survival.
• Offers an oral treatment option for advanced malignancies.
• May lead to disease stabilization or tumor regression.
• Provides a targeted therapeutic approach.

Side Effects

• Diarrhea
• Hand-foot skin reaction (palmar-plantar erythrodysesthesia)
• Fatigue
• Rash
• Nausea
• Hypertension (high blood pressure)
• Anorexia (loss of appetite)
• Weight loss
• Hair loss (alopecia)
• Voice changes (dysphonia)
• Abdominal pain
• Bleeding events

Safety Measures

• Alcohol - Avoid or limit alcohol consumption as it may exacerbate liver toxicity or other side effects associated with this medication.
• Pregnancy - Nexavar is contraindicated in pregnancy due to potential fetal harm. Effective contraception is required during treatment and for a period after.
• Breastfeeding - Breastfeeding is not recommended during treatment with Nexavar and for a period after the last dose, due to potential harm to the infant.
• Liver - Use with caution in patients with hepatic impairment; dose adjustments may be necessary. Regular liver function monitoring is crucial.
• Kidney - Generally, no dose adjustment is needed for mild to moderate renal impairment, but caution and monitoring are advised in severe cases.
• Lung - Use with caution in patients with pre-existing lung conditions, as rare but serious pulmonary adverse events can occur.

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