NITROFIX SR 30 TAB

About

Isosorbide mononitrate is a long-acting nitrate primarily used for the prophylaxis of angina pectoris. It works by releasing nitric oxide, which activates guanylate cyclase, leading to an increase in cyclic GMP in vascular smooth muscle. This results in relaxation of both arterial and venous smooth muscle, causing vasodilation. The predominant effect is venous dilation, which reduces preload and myocardial oxygen demand, while arterial dilation reduces afterload.

This sustained-release formulation ensures a consistent therapeutic effect over an extended period, helping to prevent angina attacks. By reducing the heart's workload and improving blood flow to the heart muscle, isosorbide mononitrate helps to alleviate chest pain associated with coronary artery disease. It is important to maintain a nitrate-free interval to prevent the development of tolerance to its effects.

Uses

• Prophylaxis of angina pectoris in patients with coronary artery disease.
• Long-term management of chronic stable angina.
• Adjunctive therapy in certain heart failure conditions.
• Prevention of exercise-induced angina.

Directions For Use

Take this sustained-release medication orally, usually once daily in the morning, as directed by your physician. Swallow the tablet whole; do not crush, chew, or break it.

Benefits

• Effectively prevents angina attacks.
• Reduces the frequency and severity of chest pain.
• Improves exercise tolerance in angina patients.
• Provides sustained relief from angina symptoms.
• Helps to reduce the heart's workload.
• Offers convenient once-daily dosing.

Side Effects

• Headache (very common)
• Dizziness or lightheadedness
• Flushing
• Hypotension (low blood pressure)
• Nausea or vomiting
• Tachycardia (fast heart rate)
• Weakness
• Syncope (fainting)
• Rash
• Heartburn
• Dry mouth
• Blurred vision

Safety Measures

• Alcohol - Concomitant use of alcohol can significantly enhance the hypotensive effects of nitrates, leading to severe dizziness, lightheadedness, and fainting. Avoid alcohol consumption while on this medication.
• Pregnancy - This medication is classified as Pregnancy Category C. It should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Consult your doctor.
• Breastfeeding - It is unknown whether isosorbide mononitrate is excreted in human milk. Caution should be exercised when administered to a nursing mother. Discuss with your healthcare provider.
• Liver - Use with caution in patients with severe hepatic impairment, as the metabolism of the drug may be altered. Dose adjustment may be necessary.
• Kidney - Use with caution in patients with severe renal impairment, as the elimination of the drug may be affected. Close monitoring and dose adjustment may be required.
• Lung - Generally considered safe for use in patients with lung conditions. However, caution is advised if severe hypotension could compromise respiratory function.

Disclaimer

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