Oncofluor 250mg Injection

About

Oncofluor Injection contains an antimetabolite chemotherapy agent, typically fluorouracil (5-FU), which interferes with DNA and RNA synthesis, thereby inhibiting cell growth and proliferation. This potent cytotoxic agent is primarily used in the treatment of various solid tumors, including colorectal, breast, gastric, and pancreatic cancers. Administered intravenously, 5-FU is a prodrug that is converted into active metabolites within the body. These metabolites, such as fluorodeoxyuridine monophosphate (FdUMP) and fluorouridine triphosphate (FUTP), disrupt DNA replication and repair by inhibiting thymidylate synthase and are incorporated into RNA, respectively. This dual mechanism leads to cell cycle arrest and apoptosis in rapidly dividing cancer cells. Its broad spectrum of activity makes it a cornerstone in many combination chemotherapy regimens, aiming to enhance efficacy, overcome resistance, and improve patient outcomes in advanced malignancies.

Uses

• Colorectal cancer
• Breast cancer
• Gastric cancer
• Pancreatic cancer

Directions For Use

Administered intravenously by a healthcare professional. Dosage and frequency depend on the specific cancer type and patient's condition.

Benefits

• Effective against various solid tumors
• Can be used in combination therapies
• Helps to slow cancer progression
• May improve patient survival rates
• Well-established chemotherapy agent
• Available in different strengths for tailored dosing

Side Effects

• Nausea and vomiting
• Diarrhea
• Stomatitis (mouth sores)
• Myelosuppression (low blood counts)
• Hair loss (alopecia)
• Hand-foot syndrome (palmar-plantar erythrodysesthesia)
• Fatigue
• Skin rash
• Anorexia
• Esophagitis
• Photosensitivity
• Neuropathy (rare)

Safety Measures

• Alcohol - Avoid alcohol during treatment as it may exacerbate gastrointestinal side effects and potentially interact with the medication.
• Pregnancy - Highly contraindicated in pregnancy due to severe fetal harm. Effective contraception is essential during and after treatment.
• Breastfeeding - Breastfeeding is not recommended during treatment and for a period after, as the drug can pass into breast milk and harm the infant.
• Liver - Use with caution in patients with liver impairment; dose adjustments may be necessary due to altered drug metabolism.
• Kidney - Use with caution in patients with kidney impairment; dose adjustments may be necessary as the drug and its metabolites are excreted renally.
• Lung - Rarely associated with pulmonary toxicity; monitor for respiratory symptoms, especially in patients with pre-existing lung conditions.

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