About
Paracetamol 500 mg is a widely used analgesic and antipyretic agent, primarily indicated for the relief of mild to moderate pain and reduction of fever. Its mechanism of action is thought to involve inhibition of prostaglandin synthesis predominantly within the central nervous system, leading to its pain-relieving and fever-reducing effects without significant anti-inflammatory action in peripheral tissues. It is rapidly absorbed from the gastrointestinal tract, with peak plasma concentrations typically achieved within 30 to 60 minutes after oral administration. The drug is extensively metabolized in the liver, primarily through glucuronidation and sulfation, with a small fraction metabolized via the cytochrome P450 system to a potentially toxic intermediate, N-acetyl-p-benzoquinone imine (NAPQI), which is normally detoxified by conjugation with glutathione. This medication is generally well-tolerated at therapeutic doses, making it a cornerstone in pain and fever management for various conditions.
Uses
- Relief of mild to moderate pain.
- Reduction of fever.
- Headaches and migraines.
- Musculoskeletal pain and discomfort.
Directions For Use
Take orally with water, as directed by a healthcare professional. Do not exceed the recommended dose.
Benefits
- Effective pain relief.
- Reduces fever quickly.
- Generally well-tolerated.
- Non-addictive analgesic.
- Suitable for various age groups.
- Available without prescription.
Side Effects
- Nausea
- Vomiting
- Abdominal pain
- Diarrhea
- Constipation
- Headache
- Dizziness
- Skin rash
- Allergic reactions
- Liver damage (with overdose)
- Kidney problems (rare)
- Blood disorders (rare)
Safety Measures
- Alcohol - Avoid or limit alcohol consumption as it can increase the risk of liver damage, especially with prolonged use or overdose.
- Pregnancy - Generally considered safe for use during pregnancy at recommended doses, but consult a doctor before use.
- Breastfeeding - Considered compatible with breastfeeding at therapeutic doses; minimal amounts pass into breast milk.
- Liver - Use with caution in patients with pre-existing liver disease; avoid in severe hepatic impairment.
- Kidney - Generally safe at recommended doses; use with caution in severe renal impairment.
- Lung - No specific contraindications or precautions related to lung conditions are typically noted for paracetamol.
Disclaimer
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Always consult your doctor for any medical concerns, and discuss your questions about health conditions or medications with a qualified healthcare professional. Do not ignore or delay seeking professional medical advice based on information found on Med E Hub.
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| Shop Location | Assam, India |
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