PAC MED 30mg Injection

About

PAC MED 30mg Injection contains Paclitaxel, a potent antineoplastic agent belonging to the taxane class of chemotherapy drugs. It exerts its cytotoxic effects by interfering with microtubule function, which is essential for various cellular processes, particularly cell division. Paclitaxel stabilizes microtubules, preventing their normal depolymerization and reorganization. This leads to the arrest of cancer cells in the G2/M phase of the cell cycle, ultimately inducing apoptosis (programmed cell death). This mechanism makes it effective against a wide range of solid tumors. The 30mg dose might be used in specific weekly regimens or for certain tumor types where a lower, more frequent dose is preferred to manage toxicity. It is typically administered intravenously as part of a comprehensive chemotherapy regimen.

Uses

• Ovarian cancer
• Breast cancer
• Non-small cell lung cancer
• Kaposi's sarcoma (AIDS-related)

Directions For Use

Administer intravenously under medical supervision, usually over 3-24 hours, after appropriate premedication. Follow your doctor's dosing schedule.

Benefits

• Broad spectrum anti-cancer activity.
• Induces apoptosis in cancer cells.
• Effective in various solid tumors.
• Part of established chemotherapy protocols.
• Can be used in combination therapies.
• May improve survival rates in certain cancers.

Side Effects

• Myelosuppression (neutropenia)
• Peripheral neuropathy
• Hypersensitivity reactions
• Alopecia (hair loss)
• Nausea and vomiting
• Myalgia/arthralgia (muscle/joint pain)
• Diarrhea
• Mucositis
• Bradycardia
• Hypotension
• Liver enzyme elevation
• Injection site reactions

Safety Measures

• Alcohol - Avoid alcohol, especially if liver function is compromised, as it may exacerbate liver toxicity, a known side effect of Paclitaxel.
• Pregnancy - Contraindicated in pregnancy due to significant potential for fetal harm. Effective contraception is mandatory during treatment and for a period after.
• Breastfeeding - Not recommended during breastfeeding due to potential harm to the infant; the drug may be excreted in human milk.
• Liver - Use with caution in hepatic impairment; dose adjustments are often necessary as Paclitaxel is primarily metabolized by the liver.
• Kidney - Use with caution in renal impairment; monitor kidney function, though renal excretion is a minor elimination pathway.
• Lung - Rarely, interstitial pneumonitis or pulmonary fibrosis can occur; monitor for new or worsening respiratory symptoms.

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