About

Paclilive (paclitaxel) is a highly effective antineoplastic agent belonging to the taxane class, widely used in the treatment of various solid tumors. Its primary mechanism of action involves promoting the assembly of microtubules from tubulin dimers and stabilizing them, preventing depolymerization. This leads to the inhibition of normal dynamic reorganization of the microtubule network, which is essential for vital interphase and mitotic cellular functions.

Consequently, paclitaxel arrests cells in the G2/M phase of the cell cycle and induces apoptosis, thereby inhibiting cancer cell proliferation. It is a cornerstone in the chemotherapy regimens for ovarian, breast, lung, and other cancers, often used in combination with other agents to maximize therapeutic efficacy.

Uses

Treatment of ovarian cancer.
Management of breast cancer.
Therapy for non-small cell lung cancer.
Treatment of Kaposi's sarcoma.

Directions For Use

Administer intravenously by infusion over a specified period, as directed by a healthcare professional. Premedication is required to prevent hypersensitivity reactions.

Benefits

Effective against a wide range of solid tumors.
Induces apoptosis in cancer cells.
A cornerstone in breast and ovarian cancer treatment.
Stabilizes microtubules, disrupting cell division.
Can be used in combination therapies.
Improves survival rates in various cancers.

Side Effects

Myelosuppression (neutropenia)
Peripheral neuropathy
Alopecia (hair loss)
Nausea
Vomiting
Diarrhea
Arthralgia/Myalgia
Hypersensitivity reactions
Fatigue
Mucositis
Bradycardia
Hypotension

Safety Measures

Alcohol - Avoid or limit alcohol consumption as it may exacerbate liver toxicity or gastrointestinal side effects.
Pregnancy - Contraindicated during pregnancy due to significant risk of fetal harm; effective contraception is essential.
Breastfeeding - Breastfeeding is contraindicated during treatment and for a period after the last dose due to potential harm to the infant.
Liver - Use with caution in patients with hepatic impairment; dose adjustments are often necessary based on liver function.
Kidney - No specific dose adjustment is typically required for renal impairment, but monitor closely.
Lung - Monitor for new or worsening pulmonary symptoms, including interstitial pneumonitis or radiation recall pneumonitis.

Disclaimer

MedEHub is committed to delivering reliable, expert-reviewd information to help consumers make informed health decisions. However, the content provided on this website is for informational purposes only and is not intended to replace professional medical advice, diagnosis or treatment.

Always consult your doctor for any medical concerns, and discuss your questions about health conditions or medications with a qualified healthcare professional. Do not ignore or delay seeking professional medical advice based on information found on Med E Hub.

Our goal is to complement, not replace, the essential doctor-patient relationship.

Shipping & Location