Pomired 2mg Capsule

About

Pomalidomide is an immunomodulatory drug (IMiD) primarily used in the treatment of multiple myeloma. It works by modulating the immune system, inhibiting tumor cell proliferation, and inducing apoptosis in malignant hematopoietic cells. Its mechanism involves direct anti-myeloma activity, inhibition of angiogenesis, and enhancement of host anti-tumor immunity. Pomalidomide also affects cytokine production, reducing pro-inflammatory cytokines and increasing anti-inflammatory ones, contributing to its therapeutic effects.

It is often used in combination with dexamethasone for patients who have received at least two prior therapies, including lenalidomide and a proteasome inhibitor, and have demonstrated disease progression on or within 60 days of completion of the last therapy. Its efficacy stems from its ability to overcome resistance to other IMiDs.

Uses

• Treatment of relapsed and refractory multiple myeloma.
• Used in combination with dexamethasone.
• For patients who have received prior therapies.
• Management of certain myelodysplastic syndromes (off-label in some regions).

Directions For Use

Take orally with water, usually once daily at the same time each day. Do not open, break, or chew the capsule.

Benefits

• Effective in relapsed/refractory multiple myeloma.
• Improves overall survival in eligible patients.
• Offers a treatment option after other therapies fail.
• Modulates immune response against cancer cells.
• Inhibits tumor growth and angiogenesis.
• Administered orally for convenience.

Side Effects

• Fatigue
• Neutropenia
• Thrombocytopenia
• Anemia
• Diarrhea
• Constipation
• Nausea
• Peripheral neuropathy
• Deep vein thrombosis (DVT)
• Pulmonary embolism (PE)
• Rash
• Muscle spasms

Safety Measures

• Alcohol - Avoid or limit alcohol consumption as it may exacerbate side effects like dizziness or fatigue.
• Pregnancy - Absolutely contraindicated due to severe teratogenic risk; strict contraception is required for both male and female patients.
• Breastfeeding - Not recommended as it is unknown if pomalidomide is excreted in human milk and could cause serious adverse reactions in infants.
• Liver - Use with caution in patients with hepatic impairment; dose adjustments may be necessary based on liver function.
• Kidney - Use with caution in patients with renal impairment; dose adjustments may be necessary, especially in severe cases.
• Lung - Monitor for new or worsening pulmonary symptoms, including interstitial lung disease or pulmonary hypertension.

Disclaimer

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