About
Pramipexole is a non-ergot dopamine agonist primarily used in the management of Parkinson's disease and restless legs syndrome (RLS). It works by selectively stimulating dopamine D2 and D3 receptors in the brain, mimicking the effects of natural dopamine. This action helps to restore the balance of dopamine in the brain, which is deficient in Parkinson's disease, thereby improving motor symptoms such as tremor, rigidity, and bradykinesia. For RLS, it helps to reduce the uncomfortable sensations and the urge to move the legs.
Pramipexole is effective in both early and advanced stages of Parkinson's disease, often used as monotherapy or as an adjunct to levodopa. Its extended-release formulations allow for once-daily dosing, enhancing patient compliance. Clinical studies have demonstrated its efficacy in significantly improving motor scores and reducing the frequency and severity of RLS symptoms, leading to an improved quality of life for patients.
Uses
- Treatment of Parkinson's disease (early and advanced stages).
- Management of moderate to severe primary restless legs syndrome.
- Improvement of motor symptoms like tremor, rigidity, and bradykinesia.
- Adjunctive therapy to levodopa in patients experiencing motor fluctuations.
Directions For Use
Take orally as directed by your physician, usually once daily with or without food. Do not crush, chew, or divide extended-release tablets.
Benefits
- Reduces motor symptoms of Parkinson's disease.
- Alleviates uncomfortable sensations of restless legs syndrome.
- Improves overall motor function and coordination.
- Enhances quality of life for affected individuals.
- Available in extended-release for convenient once-daily dosing.
- Non-ergot derivative with a favorable safety profile compared to older agonists.
Side Effects
- Nausea
- Dizziness
- Somnolence (sleepiness)
- Orthostatic hypotension
- Hallucinations
- Insomnia
- Constipation
- Dry mouth
- Peripheral edema
- Impulse control disorders
- Dyskinesia (with levodopa)
- Headache
Safety Measures
- Alcohol - Avoid or limit alcohol consumption as it can increase drowsiness and dizziness, exacerbating central nervous system depressant effects.
- Pregnancy - Use only if the potential benefit justifies the potential risk to the fetus. Consult your doctor; animal studies show some risk.
- Breastfeeding - Not recommended as it may inhibit lactation and is excreted in breast milk. Consult your doctor.
- Liver - Use with caution in patients with severe hepatic impairment; dose adjustment may be considered.
- Kidney - Dose adjustment is typically required based on creatinine clearance; consult your doctor for specific guidance.
- Lung - Generally safe for use in patients with lung conditions, but monitor for respiratory depression if co-administered with other CNS depressants.
Disclaimer
MedEHub is committed to delivering reliable, expert-reviewd information to help consumers make informed health decisions. However, the content provided on this website is for informational purposes only and is not intended to replace professional medical advice, diagnosis or treatment.
Always consult your doctor for any medical concerns, and discuss your questions about health conditions or medications with a qualified healthcare professional. Do not ignore or delay seeking professional medical advice based on information found on Med E Hub.
Our goal is to complement, not replace, the essential doctor-patient relationship.
| Shipping Cost |
|
| Shop Location | Assam, India |
No comments found for this product. Be the first to comment!