About
This combination medication integrates the therapeutic benefits of a non-steroidal anti-inflammatory drug (NSAID) with a prokinetic and antiemetic agent. The NSAID component, typically naproxen at 250mg, functions by inhibiting cyclooxygenase enzymes, thereby reducing the production of prostaglandins responsible for pain, inflammation, and fever. This makes it highly effective for managing various painful and inflammatory conditions. The second component, domperidone, acts as a dopamine antagonist, primarily at peripheral D2 receptors. It enhances gastrointestinal motility, accelerating gastric emptying and reducing nausea and vomiting. This dual action is particularly beneficial in situations where pain is accompanied by gastric discomfort, such as migraines or conditions where NSAID-induced dyspepsia is a concern. By combining these two agents, the medication offers comprehensive relief, addressing both the primary pain and inflammation while mitigating associated gastrointestinal symptoms, thus improving patient comfort and compliance. It is designed to provide effective symptomatic management for a range of conditions.
Uses
- Pain and inflammation with associated nausea
- Migraine headaches with gastric symptoms
- Musculoskeletal pain and stiffness
- Relief of menstrual cramps (dysmenorrhea)
Directions For Use
Take one tablet orally as prescribed by your doctor, preferably before meals to optimize the anti-nausea effect.
Benefits
- Dual action for pain relief and anti-nausea
- Reduces gastric side effects often associated with NSAIDs
- Effective for various types of pain and inflammation
- Improves patient comfort and compliance
- Faster relief from associated gastrointestinal symptoms
- Convenient dosage for combined therapy
Side Effects
- Drowsiness or dizziness
- Headache
- Dry mouth
- Abdominal pain or discomfort
- Diarrhea or constipation
- Skin rash
- Fluid retention
- Increased blood pressure
- Palpitations or irregular heartbeat (domperidone)
- Liver enzyme elevation
- Kidney function impairment
- Allergic reactions
Safety Measures
- Alcohol - Alcohol can increase the risk of gastrointestinal bleeding and liver damage when combined with the NSAID component. Avoid or limit alcohol consumption.
- Pregnancy - Avoid in late pregnancy (especially 3rd trimester) due to fetal cardiovascular risks from the NSAID. Domperidone use in pregnancy is generally not recommended unless clearly indicated.
- Breastfeeding - Both components pass into breast milk. Use with caution and consult a physician, as domperidone can increase prolactin levels.
- Liver - Use with caution in patients with hepatic impairment. Dose adjustment may be necessary, and liver function should be monitored regularly.
- Kidney - Use with caution in patients with renal impairment, as the NSAID can affect kidney function and domperidone excretion is also impacted. Dose adjustment is often required.
- Lung - Generally safe, but caution with the NSAID component in asthmatics (bronchospasm risk). Domperidone is generally safe for lung conditions.
Disclaimer
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| Shop Location | Assam, India |
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