REGLAN TAB

About

REGLAN TAB contains Metoclopramide, a dopamine D2 receptor antagonist that acts as a prokinetic agent and antiemetic. It works by increasing the tone and amplitude of gastric contractions, relaxing the pyloric sphincter, and increasing peristalsis in the duodenum and jejunum, thereby accelerating gastric emptying and intestinal transit. Additionally, it blocks dopamine receptors in the chemoreceptor trigger zone (CTZ) in the brain, which helps to reduce nausea and vomiting by preventing signals from reaching the vomiting center.

Metoclopramide is indicated for the treatment of various gastrointestinal motility disorders, including diabetic gastroparesis, and for the prevention and treatment of nausea and vomiting associated with chemotherapy, radiation therapy, or surgery. It is also used for symptomatic relief of acute and recurrent dyspepsia, providing relief from discomfort and improving digestive function.

Uses

• Diabetic gastroparesis
• Prevention of chemotherapy-induced nausea and vomiting
• Symptomatic relief of acute dyspepsia
• Gastroesophageal reflux disease (GERD)

Directions For Use

Take orally 30 minutes before meals and at bedtime, or as directed by your doctor. Do not exceed recommended dosage.

Benefits

• Accelerates gastric emptying
• Reduces nausea and vomiting
• Improves gastrointestinal motility
• Relieves symptoms of gastroparesis
• Effective antiemetic
• Can improve reflux symptoms

Side Effects

• Drowsiness
• Fatigue
• Restlessness
• Nausea
• Diarrhea
• Headache
• Dizziness
• Extrapyramidal symptoms (EPS)
• Tardive dyskinesia (long-term use)
• Depression
• Hyperprolactinemia
• Neuroleptic malignant syndrome (rare)

Safety Measures

• Alcohol - Avoid alcohol as it can increase drowsiness and other central nervous system side effects.
• Pregnancy - Generally considered safe for short-term use in pregnancy, but consult a doctor.
• Breastfeeding - Metoclopramide passes into breast milk; use with caution and monitor the infant for side effects.
• Liver - Use with caution in patients with severe liver impairment; dose adjustment may be necessary.
• Kidney - Dose adjustment is required in patients with moderate to severe renal impairment.
• Lung - Caution in patients with asthma or other respiratory conditions due to potential for bronchospasm, though rare.

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