About
Renodapt S 360mg contains mycophenolate sodium, an enteric-coated formulation of mycophenolic acid, which is an immunosuppressant. It works by selectively inhibiting inosine monophosphate dehydrogenase (IMPDH), a key enzyme in the de novo synthesis pathway of guanosine nucleotides. Lymphocytes, particularly T and B cells, are highly dependent on this pathway for their proliferation, making them sensitive to the effects of mycophenolic acid. By inhibiting lymphocyte proliferation, this medication effectively suppresses the immune response.
This targeted action helps to prevent the body's immune system from attacking and rejecting transplanted organs, such as kidneys. The enteric coating ensures that the drug is released in the small intestine, which may help to reduce gastrointestinal side effects compared to other mycophenolate formulations. It is typically used in combination with other immunosuppressive agents, like ciclosporin and corticosteroids, to provide comprehensive immunosuppression and improve the long-term survival of transplanted organs.
Uses
- Prevention of acute organ rejection in kidney transplant patients.
- Maintenance immunosuppression in kidney transplant recipients.
- Used in combination with ciclosporin and corticosteroids.
- Reduction of corticosteroid dose in some transplant patients.
Directions For Use
Take exactly as prescribed by your doctor, usually twice daily on an empty stomach. Swallow the tablet whole with water, do not crush, chew, or break.
Benefits
- Effectively prevents acute and chronic organ rejection.
- Helps maintain long-term function of transplanted kidneys.
- Enteric coating may reduce gastrointestinal side effects.
- Improves patient and graft survival rates post-transplant.
- Allows for combination therapy with other immunosuppressants.
- Provides a targeted suppression of lymphocyte proliferation.
Side Effects
- Nausea
- Diarrhea
- Vomiting
- Abdominal pain
- Leukopenia (low white blood cell count)
- Anemia (low red blood cell count)
- Thrombocytopenia (low platelet count)
- Increased risk of infections
- Headache
- Hypertension (high blood pressure)
- Insomnia
- Tremor
Safety Measures
- Alcohol - Alcohol consumption should be avoided or minimized as it may increase the risk of gastrointestinal side effects and liver toxicity.
- Pregnancy - This medication is contraindicated in pregnancy due to significant teratogenic risks. Effective contraception must be used during treatment and for a period after.
- Breastfeeding - Breastfeeding is not recommended during treatment as the drug may pass into breast milk and harm the infant.
- Liver - Use with caution in patients with severe liver impairment; dose adjustments may be necessary. Regular monitoring of liver function is advised.
- Kidney - Dose adjustments may be required in patients with severe renal impairment. Close monitoring of kidney function is essential.
- Lung - Rare cases of interstitial lung disease and pulmonary fibrosis have been reported. Monitor for new or worsening respiratory symptoms.
Disclaimer
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Always consult your doctor for any medical concerns, and discuss your questions about health conditions or medications with a qualified healthcare professional. Do not ignore or delay seeking professional medical advice based on information found on Med E Hub.
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