SANDOSTATIN LAR 20 MG INJ. VIAL.

About

Sandostatin LAR (octreotide long-acting release) 20 MG is a synthetic analog of the natural hormone somatostatin. Its primary action involves inhibiting the secretion of various hormones, including growth hormone, insulin, glucagon, and several gastrointestinal peptides. This inhibitory effect makes it a crucial therapeutic agent for managing conditions characterized by excessive hormone production, such as acromegaly and symptoms associated with neuroendocrine tumors like carcinoid syndrome and VIPomas.

The long-acting release formulation ensures a sustained therapeutic effect over an extended period, typically requiring administration once every four weeks. This not only provides consistent symptom control but also significantly enhances patient convenience and adherence to treatment, thereby improving their overall quality of life and disease management.

Uses

• Treatment of acromegaly
• Symptomatic control of neuroendocrine tumors
• Management of carcinoid syndrome
• Therapy for VIPomas

Directions For Use

Administered by deep intragluteal injection by a healthcare professional, typically once every 4 weeks.

Benefits

• Effectively suppresses hormone overproduction
• Reduces symptoms related to tumors
• Improves patient quality of life
• Convenient long-acting administration
• Proven efficacy in acromegaly
• Helps manage severe diarrhea and flushing

Side Effects

• Injection site pain or discomfort
• Diarrhea
• Abdominal pain
• Nausea
• Flatulence
• Constipation
• Gallstones or cholelithiasis
• Hyperglycemia or hypoglycemia
• Headache
• Dizziness
• Bradycardia
• Thyroid function abnormalities

Safety Measures

• Alcohol - No specific interaction, but alcohol can exacerbate gastrointestinal symptoms, which are common side effects of octreotide.
• Pregnancy - Use only if clearly needed and potential benefits outweigh risks; consult a doctor. Octreotide is classified as Category B.
• Breastfeeding - Not recommended as it is unknown if octreotide is excreted in human milk; consult a doctor.
• Liver - Use with caution in severe liver impairment; dose adjustment may be necessary due to altered metabolism.
• Kidney - Use with caution in severe kidney impairment; dose adjustment may be necessary due to altered excretion.
• Lung - No specific contraindications, but monitor for respiratory depression in rare cases, especially with high systemic exposure.

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