SANDOSTATIN LAR-30 MG INJ. VIAL.

About

Sandostatin LAR (octreotide long-acting release) 30 MG is a synthetic analog of somatostatin, a naturally occurring hormone. It functions by inhibiting the secretion of various hormones, including growth hormone, insulin, glucagon, and several gastrointestinal peptides. This mechanism makes it highly effective in managing symptoms associated with neuroendocrine tumors, such as carcinoid syndrome and VIPomas, by reducing the overproduction of these hormones. It is also a cornerstone in the treatment of acromegaly, where it helps to normalize growth hormone and IGF-1 levels.

The long-acting release formulation allows for convenient administration typically once every four weeks, providing sustained therapeutic effects and improving patient compliance and quality of life by effectively controlling disease symptoms and biochemical markers.

Uses

• Management of acromegaly
• Control of symptoms in neuroendocrine tumors
• Treatment of carcinoid syndrome
• Management of VIPomas

Directions For Use

Administered by deep intragluteal injection by a healthcare professional, typically once every 4 weeks.

Benefits

• Effectively controls hormone secretion
• Reduces tumor-related symptoms significantly
• Improves quality of life for patients
• Long-acting formulation for convenience
• Effective in managing acromegaly
• Helps prevent carcinoid crisis

Side Effects

• Injection site pain or reaction
• Diarrhea
• Abdominal pain
• Nausea
• Flatulence
• Constipation
• Gallstones or biliary sludge
• Hyperglycemia or hypoglycemia
• Headache
• Dizziness
• Bradycardia (slow heart rate)
• Thyroid dysfunction

Safety Measures

• Alcohol - No specific interaction, but alcohol can exacerbate gastrointestinal symptoms, which are common side effects of octreotide.
• Pregnancy - Use only if clearly needed and potential benefits outweigh risks; consult a doctor. Octreotide is classified as Category B.
• Breastfeeding - Not recommended as it is unknown if octreotide is excreted in human milk; consult a doctor.
• Liver - Use with caution in severe liver impairment; dose adjustment may be necessary due to altered metabolism.
• Kidney - Use with caution in severe kidney impairment; dose adjustment may be necessary due to altered excretion.
• Lung - No specific contraindications, but monitor for respiratory depression in rare cases, especially with high systemic exposure.

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