About
Letrozole is a potent and highly selective non-steroidal aromatase inhibitor, predominantly used in the treatment of hormone receptor-positive breast cancer in postmenopausal women. Its primary mechanism of action involves competitively binding to the heme of the cytochrome P450 subunit of the aromatase enzyme. This binding effectively blocks the conversion of adrenal androgens (like androstenedione and testosterone) into estrogens (estrone and estradiol) in peripheral tissues, which is the main source of estrogen in postmenopausal women. By significantly reducing systemic estrogen levels, letrozole deprives estrogen-sensitive breast cancer cells of the growth stimulus they require, thereby inhibiting tumor proliferation and recurrence. It is widely employed as adjuvant therapy following surgery, as extended adjuvant therapy, or as first-line treatment for advanced or metastatic breast cancer.
Uses
- Adjuvant treatment of early breast cancer in postmenopausal women.
- Extended adjuvant treatment of early breast cancer.
- First-line treatment of advanced breast cancer.
- Treatment of advanced breast cancer after anti-estrogen therapy failure.
Directions For Use
Take one tablet orally once daily, with or without food, at approximately the same time each day.
Benefits
- Effective in reducing breast cancer recurrence.
- Improves disease-free survival in postmenopausal women.
- Can be used in various stages of hormone-sensitive breast cancer.
- Oral administration for convenience.
- Well-established efficacy in clinical trials.
- Offers a targeted approach to hormone-sensitive cancers.
Side Effects
- Hot flashes
- Joint pain (arthralgia)
- Fatigue
- Nausea
- Headache
- Dizziness
- Bone pain
- Osteoporosis
- Hair thinning
- Weight gain
- Swelling (edema)
- Vaginal dryness
Safety Measures
- Alcohol - Moderate alcohol consumption is generally considered safe, but excessive intake may exacerbate hot flashes or liver strain.
- Pregnancy - Contraindicated in pregnancy. Letrozole can cause fetal harm; effective contraception must be used by premenopausal women.
- Breastfeeding - Contraindicated during breastfeeding. It is unknown if letrozole passes into breast milk, but potential harm to the infant is high.
- Liver - Use with caution in patients with severe liver impairment. Dosage adjustment may be necessary, and liver function should be monitored.
- Kidney - Generally safe for use in patients with kidney conditions; no specific dosage adjustment is usually required for mild to moderate impairment.
- Lung - Generally safe for use in patients with lung conditions; no specific precautions are typically needed.
Disclaimer
MedEHub is committed to delivering reliable, expert-reviewd information to help consumers make informed health decisions. However, the content provided on this website is for informational purposes only and is not intended to replace professional medical advice, diagnosis or treatment.
Always consult your doctor for any medical concerns, and discuss your questions about health conditions or medications with a qualified healthcare professional. Do not ignore or delay seeking professional medical advice based on information found on Med E Hub.
Our goal is to complement, not replace, the essential doctor-patient relationship.
| Shipping Cost |
|
| Shop Location | Assam, India |
No comments found for this product. Be the first to comment!