SGLTD M 10/1000

About

SGLTD M 10/1000 is a combination medication used in the management of type 2 diabetes mellitus. It contains Dapagliflozin, a sodium-glucose co-transporter 2 (SGLT2) inhibitor, and Metformin, a biguanide. Dapagliflozin works by inhibiting SGLT2 in the kidneys, reducing glucose reabsorption and increasing glucose excretion in the urine, thereby lowering blood glucose levels independently of insulin. Metformin primarily reduces hepatic glucose production, decreases intestinal absorption of glucose, and improves insulin sensitivity by increasing peripheral glucose uptake and utilization.

This dual mechanism of action provides comprehensive glycemic control, addressing different pathophysiological aspects of type 2 diabetes. The combination is particularly beneficial for patients who require improved glycemic control and may also benefit from the cardiovascular and renal protective effects associated with SGLT2 inhibitors, contributing to better long-term outcomes.

Uses

• Management of type 2 diabetes mellitus
• Improvement of glycemic control
• Reduction of cardiovascular risk in certain patients
• Aid in weight management for diabetic patients

Directions For Use

Take this medication orally with meals, usually twice daily, or as prescribed by your healthcare provider. Swallow the tablets whole.

Benefits

• Dual mechanism for comprehensive glucose control
• Reduces HbA1c effectively
• May promote modest weight loss
• Offers cardiovascular benefits
• Provides renal protective effects
• Improves insulin sensitivity

Side Effects

• Genital yeast infections
• Urinary tract infections
• Increased urination
• Nausea
• Diarrhea
• Abdominal discomfort
• Hypoglycemia (especially with other agents)
• Ketoacidosis (rare)
• Dehydration
• Lactic acidosis (rare, with Metformin)
• Vitamin B12 deficiency
• Taste disturbance

Safety Measures

• Alcohol - Avoid excessive alcohol intake, as it can increase the risk of lactic acidosis with Metformin.
• Pregnancy - Not recommended during pregnancy, especially in the second and third trimesters. Consult a doctor.
• Breastfeeding - Not recommended during breastfeeding as components may pass into breast milk.
• Liver - Use with caution in patients with liver impairment; Metformin is contraindicated in severe hepatic dysfunction.
• Kidney - Contraindicated in severe renal impairment (eGFR <30 mL/min/1.73m²). Dose adjustment needed for moderate impairment.
• Lung - Generally safe, but caution in conditions predisposing to hypoxia, which can increase lactic acidosis risk.

Disclaimer

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