SITAZIT D 10/50 10S

About

SITAZIT D 10/50 10S is an oral antidiabetic medication combining Dapagliflozin and Sitagliptin, used to improve glycemic control in adults with type 2 diabetes mellitus. Dapagliflozin is a sodium-glucose co-transporter 2 (SGLT2) inhibitor that works by reducing glucose reabsorption in the kidneys, leading to increased urinary glucose excretion and a subsequent reduction in blood glucose levels, independent of insulin. Sitagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor that enhances the body's natural ability to lower high blood glucose levels by increasing the active levels of incretin hormones. This dual mechanism of action provides comprehensive glycemic control, addressing different pathways involved in glucose regulation. The combination also offers benefits such as weight management and potential cardiovascular and renal protection, making it a versatile option for managing type 2 diabetes.

Uses

• Management of type 2 diabetes mellitus
• Improvement of glycemic control
• Adjunct to diet and exercise
• For patients inadequately controlled on monotherapy

Directions For Use

Take one tablet orally once daily, preferably in the morning, with or without food, as directed by your healthcare provider.

Benefits

• Lowers blood glucose effectively
• Promotes weight loss
• Offers cardiovascular benefits
• Provides renal protective effects
• Enhances natural insulin secretion
• Reduces glucagon levels

Side Effects

• Genital yeast infections
• Urinary tract infections
• Increased urination
• Nausea
• Headache
• Hypoglycemia (especially with other agents)
• Dizziness
• Back pain
• Flu-like symptoms
• Ketoacidosis (rare)
• Pancreatitis (rare)
• Joint pain (arthralgia)

Safety Measures

• Alcohol - Moderate alcohol consumption is generally acceptable, but excessive intake may increase the risk of hypoglycemia or ketoacidosis.
• Pregnancy - Not recommended during the second and third trimesters. Consult a doctor for alternative management.
• Breastfeeding - Not recommended during breastfeeding as components may pass into breast milk. Consult a doctor.
• Liver - Use with caution in patients with liver impairment. No specific dose adjustment for Sitagliptin, but Dapagliflozin data is limited.
• Kidney - Contraindicated in severe renal impairment (eGFR < 30 mL/min/1.73m²). Dose adjustment for Sitagliptin may be needed.
• Lung - No direct impact on lung conditions. However, severe illness can affect glucose control.

Disclaimer

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