STATOR F

About

STATOR F is a combination medication containing Atorvastatin and Fenofibrate, designed to manage dyslipidemia, a condition characterized by abnormal levels of lipids (fats) in the blood. Atorvastatin belongs to the statin class, which works by inhibiting HMG-CoA reductase, an enzyme crucial for cholesterol synthesis in the liver. This action effectively lowers levels of low-density lipoprotein (LDL) cholesterol, often referred to as "bad" cholesterol, and total cholesterol, while also modestly increasing high-density lipoprotein (HDL) cholesterol.

Fenofibrate is a fibric acid derivative that primarily acts by activating peroxisome proliferator-activated receptor alpha (PPARα). This activation leads to increased breakdown of triglycerides and a reduction in their production, significantly lowering very low-density lipoprotein (VLDL) and triglyceride levels. It also has a beneficial effect on increasing HDL cholesterol. The combination therapy in STATOR F provides a comprehensive approach to lipid management, particularly effective in patients with mixed dyslipidemia where both high cholesterol and high triglycerides are present, thereby reducing the risk of cardiovascular events.

Uses

• Treatment of mixed dyslipidemia.
• Reduction of elevated total cholesterol and LDL-C.
• Lowering of high triglyceride levels.
• Increasing HDL-C in patients with dyslipidemia.

Directions For Use

Take STATOR F orally once daily, preferably with food to enhance absorption of fenofibrate, or as directed by your physician.

Benefits

• Comprehensive reduction of multiple lipid fractions.
• Significantly lowers LDL ("bad") cholesterol.
• Effectively reduces high triglyceride levels.
• Modestly increases HDL ("good") cholesterol.
• Reduces the risk of cardiovascular diseases.
• Improves overall lipid profile.

Side Effects

• Muscle pain, tenderness, or weakness (myalgia).
• Elevated liver enzymes (transaminases).
• Gastrointestinal disturbances (nausea, abdominal pain).
• Headache.
• Dizziness.
• Fatigue.
• Pancreatitis (rare).
• Gallstones (cholelithiasis).
• Rash or itching.
• Joint pain (arthralgia).
• Peripheral neuropathy.
• Increased blood sugar levels.

Safety Measures

• Alcohol - Avoid excessive alcohol consumption due to increased risk of liver damage and muscle problems when combined with statins.
• Pregnancy - Contraindicated during pregnancy due to potential harm to the fetus; effective contraception should be used by women of childbearing potential.
• Breastfeeding - Contraindicated during breastfeeding as it may pass into breast milk and potentially harm the nursing infant.
• Liver - Contraindicated in patients with active liver disease or unexplained persistent elevations of serum transaminases; regular liver function tests are required.
• Kidney - Use with caution and dose adjustment may be necessary in patients with moderate to severe kidney impairment; monitor renal function.
• Lung - Rarely, interstitial lung disease has been reported with fibrates; discontinue if symptoms like dyspnea, cough, or fever develop.

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