Taxotere 80mg Injection

About

Taxotere 80mg Injection contains docetaxel, a potent taxane chemotherapy agent widely employed in the treatment of various solid tumors. Docetaxel exerts its antineoplastic effect by specifically promoting the assembly of microtubules from tubulin dimers and, crucially, simultaneously inhibiting their depolymerization. This dual action leads to the stabilization of microtubules, which are vital components of the cell's cytoskeleton and essential for cell division. The accumulation of these abnormally stable microtubules disrupts the dynamic equilibrium necessary for normal cellular mitotic and interphase functions. This disruption results in the arrest of cell division in the G2/M phase of the cell cycle and ultimately induces programmed cell death (apoptosis) in rapidly proliferating cancer cells. It is a cornerstone treatment for breast cancer, prostate cancer, non-small cell lung cancer, gastric cancer, and head and neck cancer.

Uses

• Breast cancer
• Non-small cell lung cancer (NSCLC)
• Prostate cancer
• Gastric adenocarcinoma
• Head and neck cancer

Directions For Use

Administered as an intravenous infusion by a healthcare professional. Premedication is often required to reduce hypersensitivity reactions.

Benefits

• Inhibits cancer cell division
• Effective against a broad range of solid tumors
• Can be used as monotherapy or in combination
• Improves progression-free and overall survival
• Reduces tumor size
• Offers a well-established chemotherapy option

Side Effects

• Myelosuppression (low blood counts)
• Fluid retention
• Hypersensitivity reactions
• Peripheral neuropathy
• Nausea
• Vomiting
• Diarrhea
• Hair loss (alopecia)
• Fatigue
• Stomatitis (mouth sores)
• Nail changes
• Muscle and joint pain

Safety Measures

• Alcohol - Alcohol should be avoided, especially due to the alcohol content in the formulation and potential for liver toxicity.
• Pregnancy - Taxotere is teratogenic and contraindicated in pregnancy; effective contraception is required during treatment.
• Breastfeeding - Breastfeeding is not recommended during treatment and for a period after due to potential harm to the infant.
• Liver - Use with extreme caution in patients with hepatic impairment; dose adjustments are often necessary, and liver function should be closely monitored.
• Kidney - No specific dose adjustment is typically required for renal impairment, but caution is advised; monitor kidney function.
• Lung - Patients should be monitored for new or worsening respiratory symptoms, as rare cases of interstitial pneumonitis have been reported.

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