TENVIR AF 30S

About

Tenofovir Alafenamide (TAF) is a prodrug of tenofovir, a nucleotide reverse transcriptase inhibitor (NtRTI) used in the treatment of chronic hepatitis B virus (HBV) infection and human immunodeficiency virus (HIV-1) infection. TAF is designed to deliver tenofovir more efficiently to target cells, such as hepatocytes and lymphocytes, at a lower dose compared to tenofovir disoproxil fumarate (TDF), resulting in reduced systemic exposure to tenofovir. This improved pharmacokinetic profile aims to minimize the risk of renal and bone-related adverse effects commonly associated with TDF, while maintaining potent antiviral efficacy. It works by inhibiting the activity of viral reverse transcriptase, an enzyme essential for viral replication.

The selective delivery of tenofovir to lymphoid cells and hepatocytes allows for a lower dose, which translates to a better safety profile, particularly concerning kidney function and bone mineral density, without compromising its antiviral potency. TAF is typically administered as part of a combination regimen for HIV-1 and as monotherapy for chronic HBV, offering a significant advancement in the management of these viral infections by providing an effective and generally well-tolerated treatment option.

Uses

• Treatment of chronic hepatitis B virus (HBV) infection.
• Treatment of human immunodeficiency virus type 1 (HIV-1) infection.
• Part of combination antiretroviral therapy.
• Prevention of HIV-1 infection (PrEP) in certain populations.

Directions For Use

Take orally once daily with food, as directed by your physician. Do not crush or chew the tablet.

Benefits

• Potent antiviral activity against HBV and HIV-1.
• Improved renal and bone safety profile compared to TDF.
• Convenient once-daily dosing.
• Effective in suppressing viral replication.
• Can be used in patients with mild to moderate renal impairment.
• Reduces the risk of disease progression in chronic HBV.

Side Effects

• Nausea
• Diarrhea
• Headache
• Fatigue
• Abdominal pain
• Dizziness
• Rash
• Vomiting
• Flatulence
• Increased liver enzymes
• Lactic acidosis (rare)
• Severe hepatomegaly with steatosis (rare)

Safety Measures

• Alcohol - Avoid excessive alcohol consumption as it may exacerbate liver issues, especially in patients with HBV, and could interact with the medication's metabolism.
• Pregnancy - Consult a doctor. Use only if the potential benefit justifies the potential risk to the fetus. Data on TAF use in pregnancy are limited but generally considered safer than some older antivirals.
• Breastfeeding - Consult a doctor. Tenofovir is excreted in breast milk. The decision to breastfeed should consider the risk of HIV transmission (if applicable) and potential drug effects on the infant.
• Liver - Use with caution in patients with severe hepatic impairment. Regular monitoring of liver function is essential.
• Kidney - Generally safer for kidneys than TDF, but caution is advised in severe renal impairment. Dose adjustment may be necessary; monitor renal function regularly.
• Lung - No specific contraindications or major concerns related to lung conditions are typically associated with TAF.

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