TRESIBA FLETUCH

About

TRESIBA FLETUCH refers to Insulin Degludec, an ultra-long-acting basal insulin analogue, typically administered via a FlexTouch pre-filled pen. Insulin Degludec is designed to provide a stable and prolonged glucose-lowering effect for more than 42 hours, making it suitable for once-daily dosing at any time of day, preferably at the same time each day. Upon subcutaneous injection, it forms soluble multi-hexamers that slowly release insulin monomers into the circulation, ensuring a consistent and steady glucose-lowering profile with minimal peak-to-trough fluctuations. This characteristic helps to reduce the risk of nocturnal hypoglycemia and provides greater flexibility in dosing times compared to other basal insulins. It is indicated for the treatment of diabetes mellitus in adults, adolescents, and children aged 1 year and above, requiring basal insulin for glycemic control.

Uses

• Treatment of type 1 diabetes mellitus.
• Treatment of type 2 diabetes mellitus.
• Provides basal insulin replacement.
• Aids in achieving long-term glycemic control.

Directions For Use

Inject subcutaneously once daily, at any time of day, but preferably at the same time each day. Rotate injection sites within the same region.

Benefits

• Ultra-long duration of action (over 42 hours).
• Flexible dosing time, allowing for daily adjustments.
• Reduced risk of nocturnal hypoglycemia.
• Provides stable and consistent glycemic control.
• Less day-to-day variability in glucose levels.
• Convenient pre-filled pen device for easy administration.

Side Effects

• Hypoglycemia (low blood sugar).
• Injection site reactions (pain, redness, itching, swelling).
• Lipodystrophy (fat accumulation or atrophy at injection site).
• Weight gain.
• Peripheral edema (swelling of extremities).
• Allergic reactions (rash, hives, shortness of breath).
• Pruritus (itching).
• Blurred vision (temporary, due to blood sugar changes).
• Headache.
• Flu-like symptoms.
• Antibody formation.
• Diabetic retinopathy worsening (rare).

Safety Measures

• Alcohol - Alcohol can potentiate the hypoglycemic effect of insulin; use with caution and monitor blood glucose closely.
• Pregnancy - Generally considered safe, but close monitoring and dose adjustment are crucial. Consult your doctor for personalized advice.
• Breastfeeding - Insulin is generally safe during breastfeeding, but monitor mother and infant for any adverse effects.
• Liver - Dose adjustment may be required in hepatic impairment due to altered glucose metabolism; consult your physician.
• Kidney - Dose adjustment may be required in renal impairment due to altered glucose metabolism; consult your physician.
• Lung - No specific contraindication, but general caution should be exercised in patients with severe underlying medical conditions.

Disclaimer

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