TRISIBA PENFIL

About

TRISIBA PENFIL contains Insulin Degludec, an advanced ultra-long-acting basal insulin analogue indicated for the treatment of diabetes mellitus in adults, adolescents, and children aged 1 year and above. Upon subcutaneous injection, Insulin Degludec forms soluble multi-hexamers that slowly and continuously release insulin into the systemic circulation over an extended period, exceeding 42 hours. This unique pharmacokinetic profile ensures a stable and consistent glucose-lowering effect throughout the day and night, significantly reducing the risk of nocturnal hypoglycemia compared to other basal insulins. Its prolonged action also offers considerable flexibility in dosing time, allowing patients to administer it at any time of day, provided it is taken approximately at the same time each day. TRISIBA PENFIL effectively maintains stable blood glucose levels between meals and overnight, serving as a crucial component of basal-bolus regimens or in combination with oral antidiabetic agents.

Uses

• Treatment of type 1 diabetes mellitus.
• Treatment of type 2 diabetes mellitus.
• Basal insulin therapy for glycemic control.
• Used in adults, adolescents, and children (≥1 year).

Directions For Use

Administer subcutaneously once daily at any time of day, preferably at the same time each day.

Benefits

• Ultra-long duration of action (>42 hours).
• Stable and consistent glucose lowering.
• Reduced risk of nocturnal hypoglycemia.
• Flexible dosing time.
• Improved glycemic control.
• Convenient once-daily administration.

Side Effects

• Hypoglycemia (low blood sugar)
• Injection site reactions (pain, redness, swelling)
• Lipodystrophy
• Weight gain
• Peripheral edema
• Allergic reactions (rare)
• Rash
• Pruritus
• Urticaria
• Blurred vision (transient)
• Diabetic retinopathy worsening (transient)
• Hypokalemia (rare)

Safety Measures

• Alcohol - Alcohol can lower blood sugar; use with caution and monitor glucose levels.
• Pregnancy - Consult a doctor; insulin needs may change during pregnancy.
• Breastfeeding - Generally considered safe; monitor infant for hypoglycemia.
• Liver - Use with caution; dose adjustment may be needed in severe impairment.
• Kidney - Use with caution; dose adjustment may be needed in severe impairment.
• Lung - No specific contraindications; manage diabetes carefully in patients with lung conditions.

Disclaimer

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