MPRIDE 1 MG 15'S

About

Glimepiride is an oral hypoglycemic agent classified as a second-generation sulfonylurea, widely utilized in the management of type 2 diabetes mellitus. Its primary mechanism of action involves stimulating the release of insulin from the beta cells within the pancreatic islets. This effect is mediated by binding to a specific receptor on the beta-cell surface, leading to the closure of ATP-sensitive potassium channels, subsequent depolarization, and calcium influx, which triggers insulin exocytosis. This insulinotropic action is largely glucose-dependent, meaning it is more pronounced when blood glucose levels are elevated. Furthermore, glimepiride may also contribute to improved glycemic control by enhancing the sensitivity of peripheral tissues to insulin and reducing hepatic glucose production. It is typically prescribed as an adjunct to diet and exercise when lifestyle interventions alone are insufficient to achieve target blood glucose levels, helping to prevent the progression of diabetes-related complications.

Uses

• Treatment of type 2 diabetes mellitus.
• To lower blood glucose levels.
• Used as an adjunct to diet and exercise.
• Can be used as monotherapy or in combination.

Directions For Use

Take orally once daily with the first main meal of the day. Swallow the tablet whole with water.

Benefits

• Effectively lowers blood sugar levels.
• Stimulates insulin release from the pancreas.
• Improves glycemic control.
• Can be used as monotherapy.
• Convenient once-daily dosing.
• Helps manage long-term diabetes complications.

Side Effects

• Hypoglycemia (low blood sugar)
• Nausea
• Vomiting
• Diarrhea
• Abdominal pain
• Headache
• Dizziness
• Allergic skin reactions (rash, itching)
• Weight gain
• Visual disturbances
• Liver enzyme elevation (rare)
• Blood dyscrasias (rare)

Safety Measures

• Alcohol - Avoid excessive alcohol intake, as it can increase the risk of hypoglycemia and may cause a disulfiram-like reaction.
• Pregnancy - Not recommended during pregnancy. Insulin is generally preferred for glycemic control in pregnant women with diabetes.
• Breastfeeding - Glimepiride may pass into breast milk and cause hypoglycemia in the infant. Not recommended during breastfeeding.
• Liver - Use with caution in patients with liver impairment; dose adjustment may be necessary due to altered metabolism.
• Kidney - Use with caution in patients with kidney impairment; dose adjustment may be necessary due to altered excretion.
• Lung - No specific contraindications or significant interactions with lung conditions.

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