About
Metformin and Glimepiride is a combination oral antidiabetic medication specifically formulated to enhance glycemic control in adults diagnosed with type 2 diabetes mellitus. Metformin, a biguanide, exerts its primary action by reducing the liver's glucose production and simultaneously improving the sensitivity of peripheral tissues to insulin, thereby facilitating better glucose uptake. Glimepiride, a sulfonylurea, works by stimulating the beta cells in the pancreas to release more insulin. This synergistic dual mechanism effectively targets different aspects of glucose metabolism, leading to a significant reduction in both fasting and postprandial blood glucose levels. This combination is particularly beneficial for patients whose blood sugar remains inadequately controlled despite monotherapy, offering a comprehensive approach to manage type 2 diabetes and mitigate its associated complications.
Uses
- Management of type 2 diabetes mellitus.
- Improvement of glycemic control.
- When diet and exercise alone are insufficient.
- As an adjunct to other antidiabetic therapies.
Directions For Use
Take orally with meals, usually once or twice daily, as directed by your physician. Swallow the tablet whole; do not crush or chew.
Benefits
- Effective blood sugar reduction.
- Dual mechanism of action.
- Improved insulin sensitivity.
- Reduced hepatic glucose production.
- Convenient combination therapy.
- Helps prevent diabetes complications.
Side Effects
- Hypoglycemia (low blood sugar)
- Nausea
- Diarrhea
- Abdominal pain
- Headache
- Dizziness
- Metallic taste
- Skin rash
- Weight gain
- Lactic acidosis (rare but serious)
- Vitamin B12 deficiency
- Upper respiratory tract infection
Safety Measures
- Alcohol - Avoid excessive alcohol consumption as it can increase the risk of hypoglycemia and lactic acidosis, especially with Metformin.
- Pregnancy - Generally not recommended during pregnancy. Insulin is often preferred for glycemic control in pregnant women with diabetes. Consult your doctor.
- Breastfeeding - Not recommended during breastfeeding as components may pass into breast milk and potentially harm the infant. Seek medical advice.
- Liver - Use with caution in patients with liver impairment as it may increase the risk of lactic acidosis (Metformin) and affect drug metabolism. Regular monitoring is advised.
- Kidney - Contraindicated in severe renal impairment due to increased risk of lactic acidosis (Metformin). Dose adjustment is necessary for moderate impairment.
- Lung - No specific contraindications related to lung conditions, but severe respiratory insufficiency can increase the risk of lactic acidosis.
Disclaimer
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Always consult your doctor for any medical concerns, and discuss your questions about health conditions or medications with a qualified healthcare professional. Do not ignore or delay seeking professional medical advice based on information found on Med E Hub.
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