DUOPIL 2/500 10S

About

DUOPIL 2/500 is a combination medication prescribed for the management of Type 2 Diabetes Mellitus. It comprises Glimepiride, a sulfonylurea, and Metformin, a biguanide. Glimepiride acts by stimulating the beta cells of the pancreas to release more insulin, thereby lowering blood glucose levels. Metformin primarily works by reducing hepatic glucose production, decreasing intestinal absorption of glucose, and improving insulin sensitivity in peripheral tissues. This synergistic action addresses multiple facets of hyperglycemia, making it highly effective for patients whose blood sugar is not adequately controlled by diet, exercise, or monotherapy with either agent. The combination helps achieve better glycemic control, evidenced by reduced HbA1c levels, and contributes to mitigating the long-term complications associated with diabetes. Its comprehensive approach often allows for optimized dosing and enhanced therapeutic outcomes.

Uses

• Management of Type 2 Diabetes Mellitus
• To improve glycemic control in adults
• As an adjunct to diet and exercise
• When monotherapy is insufficient

Directions For Use

Take this medication orally, usually once or twice daily with meals, or as directed by your physician. Swallow the tablet whole with water.

Benefits

• Effective blood sugar control
• Reduced HbA1c levels
• Dual mechanism of action
• Improved insulin sensitivity
• Reduced risk of diabetic complications
• Convenient combination therapy

Side Effects

• Hypoglycemia (low blood sugar)
• Nausea
• Diarrhea
• Abdominal pain
• Headache
• Dizziness
• Metallic taste
• Lactic acidosis (rare but serious)
• Weight gain (less common with metformin)
• Skin rash
• Upper respiratory tract infection
• Vitamin B12 deficiency (long-term use)

Safety Measures

• Alcohol - Avoid excessive alcohol consumption as it can increase the risk of hypoglycemia and lactic acidosis, especially with metformin.
• Pregnancy - Generally not recommended during pregnancy. Consult your doctor; insulin may be preferred for glycemic control.
• Breastfeeding - Not advised during breastfeeding as components may pass into breast milk. Consult your doctor.
• Liver - Use with caution in patients with liver impairment; dose adjustment may be necessary. Contraindicated in severe hepatic failure.
• Kidney - Use with caution and dose adjustment in patients with kidney impairment. Contraindicated in severe renal failure due to metformin accumulation risk.
• Lung - No specific contraindication for lung conditions, but severe respiratory insufficiency may increase lactic acidosis risk.

Disclaimer

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