GLIMY M2 FORTE 10S

About

This medication is a combination therapy for Type 2 Diabetes Mellitus, featuring glimepiride, a sulfonylurea, and metformin, a biguanide. Glimepiride primarily functions by stimulating the beta cells in the pancreas to release more insulin, thereby lowering blood glucose levels. Metformin, on the other hand, works through multiple mechanisms: it significantly reduces glucose production in the liver, decreases the absorption of glucose from the intestines, and importantly, enhances the body's sensitivity to insulin, allowing cells to utilize glucose more effectively. This dual action provides a comprehensive and complementary approach to managing hyperglycemia, aiming to improve overall glycemic control in adult patients whose blood sugar levels are not adequately managed by diet and exercise alone, or by monotherapy with either agent. The synergistic effect of these two agents helps to achieve better therapeutic outcomes and reduce the risk of long-term diabetic complications.

Uses

• Management of Type 2 Diabetes Mellitus.
• To achieve better glycemic control.
• When monotherapy is insufficient.
• As an adjunct to diet and exercise.

Directions For Use

Take orally with meals, usually once or twice daily, as prescribed by your doctor. Swallow whole.

Benefits

• Significant reduction in blood glucose.
• Dual mechanism of action.
• Improved insulin utilization.
• Reduced risk of microvascular complications.
• May contribute to weight stability (metformin).
• Convenient fixed-dose regimen.

Side Effects

• Hypoglycemia (low blood sugar)
• Nausea
• Vomiting
• Diarrhea
• Abdominal discomfort
• Headache
• Dizziness
• Metallic taste
• Skin rash
• Lactic acidosis (rare, serious)
• Vitamin B12 deficiency
• Weight gain (less common with metformin)

Safety Measures

• Alcohol - Avoid excessive alcohol consumption as it can increase the risk of hypoglycemia and lactic acidosis.
• Pregnancy - Not recommended during pregnancy; insulin is generally preferred. Consult your healthcare provider.
• Breastfeeding - Metformin passes into breast milk; glimepiride data is limited. Use with caution and medical advice.
• Liver - Use with caution in patients with liver impairment; may increase risk of hypoglycemia and lactic acidosis.
• Kidney - Contraindicated in severe renal impairment due to increased risk of lactic acidosis. Dose adjustment needed for moderate impairment.
• Lung - Use with caution in severe respiratory conditions that may predispose to hypoxia and lactic acidosis.

Disclaimer

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