About
This medication is a fixed-dose combination of Metformin and Glimepiride, designed for enhanced management of type 2 diabetes mellitus in adults. Metformin, a biguanide, works by reducing glucose production in the liver and improving insulin sensitivity in peripheral tissues. Glimepiride, a sulfonylurea, stimulates the pancreatic beta cells to release more insulin.
This synergistic action effectively addresses both insulin resistance and inadequate insulin secretion, providing comprehensive glycemic control. It is typically prescribed when diet, exercise, and monotherapy with either metformin or glimepiride alone are insufficient to achieve target blood glucose levels, offering a robust approach to managing hyperglycemia and improving patient outcomes.
Uses
- Treatment of type 2 diabetes.
- Improved blood glucose control.
- When monotherapy is inadequate.
- As an adjunct to lifestyle changes.
Directions For Use
Take orally with meals, usually once or twice daily, as directed by your physician. Maintain a consistent meal schedule.
Benefits
- Provides powerful glycemic control.
- Addresses multiple pathophysiological defects.
- Significantly lowers HbA1c.
- Controls both fasting and postprandial glucose.
- Offers the convenience of a single tablet.
- Potent and well-established combination.
Side Effects
- Hypoglycemia
- Nausea
- Diarrhea
- Abdominal discomfort
- Headache
- Dizziness
- Weight gain
- Skin rash
- Photosensitivity
- Lactic acidosis (rare)
- Vitamin B12 deficiency
- Taste disturbance
Safety Measures
- Alcohol - Avoid alcohol consumption as it can significantly increase the risk of severe hypoglycemia and also elevate the risk of lactic acidosis.
- Pregnancy - Contraindicated. Glimepiride is known to be harmful in pregnancy, and while metformin has some use, combination therapy is generally not recommended.
- Breastfeeding - Contraindicated. Glimepiride passes into breast milk and can cause hypoglycemia in the infant. Metformin is generally safe, but the combination is not advised.
- Liver - Use with extreme caution or avoid in severe hepatic impairment due to increased risk of hypoglycemia and lactic acidosis. Close monitoring is essential.
- Kidney - Contraindicated in severe renal impairment (eGFR <30 mL/min/1.73m²). Careful dose adjustment is necessary for moderate impairment to prevent drug accumulation.
- Lung - Patients with severe acute or chronic lung conditions leading to hypoxia should use this combination with caution, as hypoxia can increase the risk of lactic acidosis.
Disclaimer
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Always consult your doctor for any medical concerns, and discuss your questions about health conditions or medications with a qualified healthcare professional. Do not ignore or delay seeking professional medical advice based on information found on Med E Hub.
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