GLUCORYL-2 10 S

About

Glimepiride 2mg is an oral hypoglycemic agent belonging to the sulfonylurea class, primarily used in the management of type 2 diabetes mellitus. Its main mechanism of action involves stimulating insulin secretion from the beta cells of the pancreatic islets. This action is glucose-dependent, meaning it is more pronounced when blood glucose levels are elevated, thereby reducing the risk of severe hypoglycemia compared to older sulfonylureas. Glimepiride binds to a specific receptor on the pancreatic beta cell membrane, leading to the closure of ATP-sensitive potassium channels, depolarization of the membrane, and subsequent influx of calcium ions. This calcium influx triggers the release of stored insulin. Additionally, glimepiride may improve peripheral insulin sensitivity and reduce hepatic glucose production, contributing to overall glycemic control when diet and exercise alone are insufficient.

Uses

• Treatment of type 2 diabetes mellitus.
• Lowering of high blood glucose levels.
• Used as monotherapy or in combination.
• When diet and exercise are inadequate.

Directions For Use

Take orally, usually once daily with breakfast or the first main meal, as directed by your physician. Swallow the tablet whole with water.

Benefits

• Effective reduction in blood glucose levels.
• Stimulates insulin release.
• Can be used as monotherapy.
• Well-established treatment option.
• May improve insulin sensitivity.
• Convenient once-daily dosing.

Side Effects

• Hypoglycemia (most common)
• Nausea
• Vomiting
• Diarrhea
• Abdominal pain
• Headache
• Dizziness
• Allergic skin reactions (e.g., rash, pruritus)
• Weight gain
• Transient visual disturbances
• Abnormal liver function tests
• Hematological changes (rare, e.g., leukopenia)

Safety Measures

• Alcohol - Avoid excessive alcohol consumption as it can potentiate the hypoglycemic effect of glimepiride and may cause a disulfiram-like reaction.
• Pregnancy - Not recommended during pregnancy due to potential for fetal hypoglycemia. Insulin is generally preferred for glycemic control in pregnant women.
• Breastfeeding - Not recommended during breastfeeding as glimepiride may pass into breast milk and cause hypoglycemia in the infant.
• Liver - Use with caution in patients with hepatic impairment. Dose adjustment may be necessary, and it is contraindicated in severe liver disease.
• Kidney - Use with caution in patients with renal impairment. Dose adjustment may be required to avoid accumulation and increased risk of hypoglycemia.
• Lung - No specific contraindications related to lung conditions, but general caution applies in severe systemic illness.

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