About
This medication is a fixed-dose combination of Metformin and Pioglitazone, indicated for the comprehensive management of type 2 diabetes mellitus in adults. Metformin, a biguanide, primarily reduces hepatic glucose production and enhances insulin sensitivity in peripheral tissues. Pioglitazone, a thiazolidinedione (TZD), improves insulin sensitivity in muscle, adipose tissue, and the liver by activating peroxisome proliferator-activated receptor-gamma (PPAR-gamma).
This synergistic action effectively addresses insulin resistance, a fundamental defect in type 2 diabetes, leading to improved glycemic control. It is typically prescribed for adults when diet, exercise, and monotherapy with either metformin or pioglitazone alone do not achieve adequate blood sugar control, providing a robust approach to managing hyperglycemia.
Uses
- Treatment of type 2 diabetes.
- Enhanced insulin sensitivity.
- Improved blood glucose regulation.
- As an adjunct to lifestyle modifications.
Directions For Use
Take orally once daily with or without food, as prescribed by your doctor. Adhere strictly to the dosage regimen.
Benefits
- Provides robust blood glucose reduction.
- Directly targets underlying insulin resistance.
- Offers sustained glycemic control.
- May positively impact lipid profiles.
- Convenient once-daily dosing.
- Reduces HbA1c effectively.
Side Effects
- Weight gain
- Edema/fluid retention
- Upper respiratory infection
- Headache
- Sinusitis
- Myalgia
- Hypoglycemia (low risk)
- Increased risk of fractures
- Rare bladder cancer risk
- Macular edema
- Lactic acidosis (rare)
- Exacerbation of heart failure
Safety Measures
- Alcohol - Avoid excessive alcohol intake as it can increase the risk of lactic acidosis (due to metformin) and may impair blood sugar control.
- Pregnancy - Not recommended. Pioglitazone is generally contraindicated in pregnancy, and while metformin may be used, combination therapy is usually avoided.
- Breastfeeding - Not recommended. Pioglitazone is not advised during breastfeeding, and while metformin is generally safe, the combination should be avoided.
- Liver - Contraindicated in active liver disease or elevated liver enzymes. Regular monitoring of liver function tests is required before and during treatment.
- Kidney - Contraindicated in severe renal impairment (eGFR <30 mL/min/1.73m²). Dose adjustments for metformin are crucial for moderate impairment. Pioglitazone does not require renal adjustment.
- Lung - Use with caution in patients with severe lung conditions, especially those leading to hypoxia, as this can increase the risk of lactic acidosis.
Disclaimer
MedEHub is committed to delivering reliable, expert-reviewd information to help consumers make informed health decisions. However, the content provided on this website is for informational purposes only and is not intended to replace professional medical advice, diagnosis or treatment.
Always consult your doctor for any medical concerns, and discuss your questions about health conditions or medications with a qualified healthcare professional. Do not ignore or delay seeking professional medical advice based on information found on Med E Hub.
Our goal is to complement, not replace, the essential doctor-patient relationship.
| Shipping Cost |
|
| Shop Location | Assam, India |
No comments found for this product. Be the first to comment!