TRIGULIN 2MG 15S

About

Trigulin tablets contain glimepiride, a sulfonylurea antidiabetic agent used to manage type 2 diabetes mellitus. Glimepiride primarily works by stimulating the beta cells in the pancreas to release more insulin, particularly in the presence of glucose. This increased insulin secretion helps to lower blood glucose levels by facilitating glucose uptake into peripheral tissues and reducing hepatic glucose production. It is a potent agent that can significantly reduce both fasting and postprandial blood glucose levels, leading to improved HbA1c. Glimepiride is typically prescribed when diet, exercise, and weight reduction alone are insufficient to control blood sugar. It is often used as monotherapy or in combination with other antidiabetic medications, such as metformin, to achieve optimal glycemic targets.

Uses

• Management of type 2 diabetes mellitus.
• As an adjunct to diet and exercise.
• To lower fasting and postprandial blood glucose.
• When other therapies are inadequate.

Directions For Use

Take orally once daily, preferably with the first main meal of the day. Do not crush or chew the tablet.

Benefits

• Effectively lowers blood glucose levels.
• Significantly reduces HbA1c.
• Stimulates insulin secretion.
• Can be used as monotherapy.
• Available in convenient once-daily dosing.
• Well-established efficacy in diabetes management.

Side Effects

• Hypoglycemia (most common)
• Nausea
• Vomiting
• Diarrhea
• Abdominal pain
• Headache
• Dizziness
• Allergic skin reactions (rash, itching)
• Weight gain
• Liver enzyme elevation (rare)
• Blood dyscrasias (rare)
• Photosensitivity

Safety Measures

• Alcohol - Avoid excessive alcohol consumption as it can increase the risk of hypoglycemia and may cause a disulfiram-like reaction.
• Pregnancy - Not recommended during pregnancy due to potential harm to the fetus and risk of neonatal hypoglycemia.
• Breastfeeding - Not advised during breastfeeding as glimepiride may pass into breast milk and cause hypoglycemia in the infant.
• Liver - Use with caution in patients with liver impairment. Dose adjustment may be necessary, and regular monitoring is advised.
• Kidney - Use with caution in patients with renal impairment. Dose adjustment is often required to prevent accumulation and hypoglycemia.
• Lung - No specific contraindications related to lung conditions, but general caution applies in severe systemic illness.

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